The DOI matches its Crossref record.
Highly Cooperative Opening of Calcium Channels by Inositol 1,4,5-Trisphosphate
Abstract
The kinetics of calcium release by inositol 1,4,5-trisphosphate (IP 3 ) in permeabilized rat basophilic leukemia cells were studied to obtain insight into the molecular mechanism of action of this intracellular messenger of the phosphoinositide cascade. Calcium release from intracellular storage sites was monitored with fura-2, a fluorescent indicator. The dependence of the rate of calcium release on the concentration of added IP 3 in the 4 to 40 n M range showed that channel opening requires the binding of at least three molecules of IP 3 . Channel opening occurred in the absence of added adenosine triphosphate, indicating that IP 3 acts directly on the channel or on a protein that gates it. The channels were opened by IP 3 in less than 4 seconds. The highly cooperative opening of calcium channels by nanomolar concentrations of IP 3 enables cells to detect and amplify very small changes in the concentration of this messenger in response to hormonal, sensory, and growth control stimuli.
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Cited by
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
THE HIGH-AFFINITY I g E RECEPTOR (FcεRI): From Physiology to Pathology
Kinet, J.-P. (1999) · Annual Review of Immunology · doi:10.1146/annurev.immunol.17.1.931 · Cited by 968
Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release
Finch, E. A., Turner, T. J., & Goldin, S. M. (1991) · Science · doi:10.1126/science.2017683 · Cited by 850
Simonson, M. S., Wann, S., Mené, P., Dubyak, G. R., Kester, M., Nakazato, Y., Sedor, J. R., & Dunn, M. J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci113935 · Cited by 555
Molecular model for receptor-stimulated calcium spiking.
Meyer, T., & Stryer, L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5051 · Cited by 414
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Metadata
- Authors
- Meyer, T., Holowka, D., & Stryer, L.
- Venue
- Science
- Published
- 1988-04-29
- Volume
- 240
- Issue
- 4852
- Pages
- 653-656
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2054753751
- Cited by
- 310
- References
- 0
- FWCI
- 20.51
- Type
- journal article
- Language
- en
- Open access
- closed
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