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Cited by 850

The DOI matches its Crossref record.

Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release

Finch, Elizabeth A., Turner, Timothy J., Goldin, Stanley M.·1991·Science
DOI 10.1126/science.2017683
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Abstract

Inositol 1,4,5-trisphosphate (IP 3 )-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium levels. The subsecond kinetics and regulation of IP 3 -induced calcium-45 release from synaptosome-derived microsomal vesicles were resolved by rapid superfusion. Extravesicular calcium acted as a coagonist, potentiating the transient IP 3 -induced release of calcium-45. Thus, rapid elevation of cytosolic calcium levels may trigger IP 3 -induced calcium release in vivo. Extravesicular calcium also produced a more slowly developing, reversible inhibition of IP 3 -induced calcium-45 release. Sequential positive and negative feedback regulation by calcium of IP 3 -induced calcium release may contribute to transients and oscillations of cytosolic-free calcium in vivo.

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Metadata

Authors
Finch, E. A., Turner, T. J., & Goldin, S. M.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1991-04-19
Volume
252
Issue
5004
Pages
443-446
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2017683
OpenAlex
W2091368852
Cited by
850
References
0
FWCI
48.15
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release. https://app.cochat.ai/papers/10.1126/science.2017683
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Finch, E. A., Turner, T. J., & Goldin, S. M. (1991). Calcium as a Coagonist of Inositol 1,4,5-Trisphosphate-Induced Calcium Release. Science. https://doi.org/10.1126/science.2017683

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.