The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease
Abstract
In situ hybridization was used to assess total amyloid protein precursor (APP) messenger RNA and the subset of APP mRNA containing the Kunitz protease inhibitor (KPI) insert in 11 Alzheimer's disease (AD) and 7 control brains. In AD, a significant twofold increase was observed in total APP mRNA in nucleus basalis and locus ceruleus neurons but not in hippocampal subicular neurons, neurons of the basis pontis, or occipital cortical neurons. The increase in total APP mRNA in locus ceruleus and nucleus basalis neurons was due exclusively to an increase in APP mRNA lacking the KPI domain. These findings suggest that increased production of APP lacking the KPI domain in nucleus basalis and locus ceruleus neurons may play an important role in the deposition of cerebral amyloid that occurs in AD.
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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Kang, J., Lemaire, H.-G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzeschik, K.-H., Multhaup, G., Beyreuther, K., & Müller-Hill, B. (1987) · Nature · doi:10.1038/325733a0 · Cited by 4,619
Amyloid plaque core protein in Alzheimer disease and Down syndrome.
Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., & Beyreuther, K. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.12.4245 · Cited by 4,431
Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain
Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627
Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus
Tanzi, R. E., Gusella, J. F., Watkins, P. C., Bruns, G. A. P., St George-Hyslop, P., Van Keuren, M. L., Patterson, D., Pagan, S., Kurnit, D. M., & Neve, R. L. (1987) · Science · doi:10.1126/science.2949367 · Cited by 1,611
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Cited by
Review Article: Genetics of Alzheimer Disease
Bekris, L. M., Yu, C.-E., Bird, T. D., & Tsuang, D. W. (2010) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988710383571 · Cited by 1,029
Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport.
Koo, E. H., Sisodia, S. S., Archer, D. R., Martin, L. J., Weidemann, A., Beyreuther, K., Fischer, P., Masters, C. L., & Price, D. L. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1561 · Cited by 733
Anandatheerthavarada, H. K., Biswas, G., Robin, M.-A., & Avadhani, N. G. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200207030 · Cited by 571
“…at an early age, is often associated with mutations in APP, whereas the sporadic form, which manifests at later stages of life, is reported to be multifactorial, including induced expression of APP (Cohen et al., 1988; Palmert et al., 1988; Jacobsen et al., 1991; Rockenstein et al., 1995).”
BackgroundSolution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition
Barrow, C. J., & Zagorski, M. G. (1991) · Science · doi:10.1126/science.1853202 · Cited by 537
A review of molecular recognition technologies for detection of biological threat agents
Iqbal, S. S., Mayo, M. W., Bruno, J. G., Bronk, B. V., Batt, C. A., & Chambers, J. P. (2000) · Biosensors and Bioelectronics · doi:10.1016/s0956-5663(00)00108-1 · Cited by 507
Metadata
- Authors
- Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., Usiak, M. F., Younkin, L. H., & Younkin, S. G.
- Venue
- Science
- Published
- 1988-08-26
- Volume
- 241
- Issue
- 4869
- Pages
- 1080-1084
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044476913
- Cited by
- 256
- References
- 4
- FWCI
- 32.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- Palmert, M. R., Golde, T. E., Cohen, M. L., Kovacs, D. M., Tanzi, R. E., Gusella, J. F., Usiak, M. F., Younkin, L. H., & Younkin, S. G. (1988). Amyloid Protein Precursor Messenger RNAs: Differential Expression in Alzheimer's Disease. Science. https://doi.org/10.1126/science.2457949
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
