Review Article: Genetics of Alzheimer Disease

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Alzheimer's Disease: Genes, Proteins, and Therapy

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Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

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The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

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Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

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β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

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Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

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A Century of Alzheimer's Disease

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A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

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Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

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Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Visualization of Aβ42(43) and Aβ40 in senile plaques with end-specific Aβ monoclonals: Evidence that an initially deposited species is Aβ42(43)

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Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

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Frequency of Stages of Alzheimer-Related Lesions in Different Age Categories

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An Increased Percentage of Long Amyloid β Protein Secreted by Familial Amyloid β Protein Precursor (βApp ₇₁₇ ) Mutants

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Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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Alzheimer's Disease and Parkinson's Disease

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Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

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Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

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Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein

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Apolipoprotein E polymorphism and Alzheimer's disease

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Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

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Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

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A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

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Evidence that production and release of amyloid beta-protein involves the endocytic pathway

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Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s Disease

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Skeletal and CNS Defects in Presenilin-1-Deficient Mice

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Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

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Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer’s disease

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Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

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Evidence that β-Amyloid Protein in Alzheimer's Disease Is Not Derived by Normal Processing

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Reconstitution of γ-secretase activity

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The role of presenilin cofactors in the γ-secretase complex

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A Familial Alzheimer's Disease Locus on Chromosome 1

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Dementia and Alzheimer Disease Incidence: A Prospective Cohort Study

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aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

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Accumulation of amyloid precursor protein in the mitochondrial import channels of human Alzheimer's disease brain is associated with mitochondrial dysfunction

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BACE1 is the major β-secretase for generation of Aβ peptides by neurons

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The Relationship between Aβ and Memory in the Tg2576 Mouse Model of Alzheimer's Disease

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APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

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Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant.

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2023 Alzheimer's disease facts and figures

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Comprehensive Review on Alzheimer’s Disease: Causes and Treatment

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2024 Alzheimer's disease facts and figures

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2019 Alzheimer’s disease facts and figures.

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2020 Alzheimer's disease facts and figures

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2018 Alzheimer's disease facts and figures

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Amyloid β-based therapy for Alzheimer’s disease: Challenges, successes and future

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Uncovering the heterogeneity and temporal complexity of neurodegenerative diseases with subtype and Stage inference

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Alzheimer's Disease: Treatment Strategies and Their Limitations.

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Neurocognitive Impairment in Obstructive Sleep Apnea

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Genetic counseling and testing for Alzheimer disease: Joint practice guidelines of the American College of Medical Genetics and the National Society of Genetic Counselors

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Proteolytic Degradation of Amyloid -Protein

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Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection

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Genes associated with Alzheimer&amp;#39;s disease: an overview and current status

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Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review

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Oxidative stress and β-amyloid protein in Alzheimer’s disease

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Sexually divergent induction of microglial-associated neuroinflammation with hippocampal aging

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APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

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β-Amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1

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PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

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Nonhuman Primate Models of Alzheimer-Like Cerebral Proteopathy

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Molecular diagnostics of neurodegenerative disorders

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Atrophy of presubiculum and subiculum is the earliest hippocampal anatomical marker of Alzheimer's disease

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Endo‐lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease?

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Mechanisms of protein toxicity in neurodegenerative diseases

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Complement receptor 1 (CR1) and Alzheimer's disease

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Neurotheranostics as Personalized Medicines

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Genetic architecture of Alzheimer's disease

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Redox proteomics and amyloid β-peptide: Insights into Alzheimer disease

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Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm

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Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s disease

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Nutrients for neurocognition in health and disease: Measures, methodologies and mechanisms

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Sex-Specific Cross Tissue Meta-Analysis Identifies Immune Dysregulation in Women With Alzheimer’s Disease

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Addressing the Discrepancies Between Animal Models and Human Alzheimer’s Disease Pathology: Implications for Translational Research

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Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice

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The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment

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Metformin: A Growing Journey from Glycemic Control to the Treatment of Alzheimer’s Disease and Depression

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Using machine intelligence to uncover Alzheimer’s disease progression heterogeneity

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The mTOR pathway: a common link between Alzheimer's disease and Down Syndrome

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Molecular diagnosis of autosomal dominant early onset Alzheimer’s disease: an update: Table 1

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Systematic validation of variants of unknown significance in PSEN1

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P4-140 Mutational analysis of PSEN1, PSEN2 and APP in a Japanese population

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Identification of the Third Case of PSEN1 Tyr389His Variant in Early-Onset Alzheimer’s Disease in Korea

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Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life

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