The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons
Open accessAbstract
The ion current induced by the glutamate receptor agonist N -methyl-D-aspartate (NMDA) in voltage-clamped hippocampal neurons was inhibited by ethanol (EtOH). Inhibition increased in a concentration-dependent manner over the range 5 to 50 m M , a range that also produces intoxication. The amplitude of the NMDA-activated current was reduced 61 percent by 50 m M EtOH; in contrast, this concentration of EtOH reduced the amplitude of current activated by the glutamate receptor agonists kainate and quisqualate by only 18 and 15 percent, respectively. The potency for inhibition of the NMDA-activated current by several alcohols is linearly related to their intoxicating potency, suggesting that alcohol-induced inhibition of responses to NMDA receptor activation may contribute to the neural and cognitive impairments associated with intoxication.
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Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Cellular and molecular mechanisms of drug dependence
Koob, G. F., & Bloom, F. E. (1988) · Science · doi:10.1126/science.2903550 · Cited by 2,070
NMDA application potentiates synaptic transmission in the hippocampus
Kauer, J. A., Malenka, R. C., & Nicoll, R. A. (1988) · Nature · doi:10.1038/334250a0 · Cited by 423
Cited by
Danbolt, N. C. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(00)00067-8 · Cited by 4,227
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
Traynelis, S. F., Wollmuth, L. P., McBain, C. J., Menniti, F. S., Vance, K. M., Ogden, K. K., Hansen, K. B., Yuan, H., Myers, S. J., & Dingledine, R. (2010) · Pharmacological Reviews · doi:10.1124/pr.109.002451 · Cited by 3,568
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953
Blockade of NMDA Receptors and Apoptotic Neurodegeneration in the Developing Brain
Ikonomidou, C., Bosch, F., Miksa, M., Bittigau, P., Vöckler, J., Dikranian, K., Tenkova, T. I., Stefovska, V., Turski, L., & Olney, J. W. (1999) · Science · doi:10.1126/science.283.5398.70 · Cited by 2,055
Metadata
- Authors
- Lovinger, D. M., White, G., & Weight, F. F.
- Venue
- Science
- Published
- 1989-03-31
- Volume
- 243
- Issue
- 4899
- Pages
- 1721-1724
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2073537077
- Cited by
- 1,448
- References
- 3
- FWCI
- 21.78
- Type
- journal article
- Language
- en
- Open access
- green
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- Lovinger, D. M., White, G., & Weight, F. F. (1989). Ethanol Inhibits NMDA-Activated Ion Current in Hippocampal Neurons. Science. https://doi.org/10.1126/science.2467382
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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