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Breaking the Diffraction Barrier: Optical Microscopy on a Nanometric Scale
Abstract
In near-field scanning optical microscopy, a light source or detector with dimensions less than the wavelength (λ) is placed in close proximity (<λ/50) to a sample to generate images with resolution better than the diffraction limit. A near-field probe has been developed that yields a resolution of ∼12 nm (∼λ/43) and signals ∼10 4 - to 10 6 -fold larger than those reported previously. In addition, image contrast is demonstrated to be highly polarization dependent. With these probes, near-field microscopy appears poised to fulfill its promise by combining the power of optical characterization methods with nanometric spatial resolution.
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Citations
Cited by
Ghosh, S. K., & Pal, T. (2007) · Chemical Reviews · doi:10.1021/cr0680282 · Cited by 2,782
Super-resolution fluorescence microscopy
Huang, B., Bates, M., & Zhuang, X. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061906.092014 · Cited by 1,657
Imaging with terahertz radiation
Chan, W. L., Deibel, J., & Mittleman, D. M. (2007) · Reports on Progress in Physics · doi:10.1088/0034-4885/70/8/r02 · Cited by 965
Probing Individual Molecules with Confocal Fluorescence Microscopy
Nie, S., Chiu, D. T., & Zare, R. N. (1994) · Science · doi:10.1126/science.7973650 · Cited by 549
Near-Field Scanning Optical Microscopy
Dunn, R. C. (1999) · Chemical Reviews · doi:10.1021/cr980130e · Cited by 508
Metadata
- Authors
- Betzig, E., Trautman, J. K., Harris, T. D., Weiner, J. S., & Kostelak, R. L.
- Venue
- Science
- Published
- 1991-03-22
- Volume
- 251
- Issue
- 5000
- Pages
- 1468-1470
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1970528721
- Cited by
- 1,534
- References
- 0
- FWCI
- 43.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Betzig, E., Trautman, J. K., Harris, T. D., Weiner, J. S., & Kostelak, R. L. (1991). Breaking the Diffraction Barrier: Optical Microscopy on a Nanometric Scale. Science. https://doi.org/10.1126/science.251.5000.1468
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