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Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors
Abstract
The neutrophil Mac-1 and gp100 MEL-14 adhesion proteins are involved in neutrophil extravasation during inflammation. Both the expression and activity of Mac-1 are greatly increased after neutrophil activation. In contrast, neutrophils shed gp100 MEL-14 from the cell surface within 4 minutes after activation with chemotactic factors or phorbol esters, releasing a 96-kilodalton fragment of the antigen into the supernatant. Immunohistology showed that gp100 MEL-14 was downregulated on neutrophils that had extravasated into inflamed tissue. The gp100 MEL-14 adhesion protein may participate in the binding of unactivated neutrophils to the endothelium; rapid shedding of gp100 MEL-14 may prevent extravasation into and damage of normal tissues by activated neutrophils.
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Cites
Involvement of Sialic Acid on Endothelial Cells in Organ-Specific Lymphocyte Recirculation
Rosen, S. D., Singer, M. S., Yednock, T. A., & Stoolman, L. M. (1985) · Science · doi:10.1126/science.4001928 · Cited by 235
Cited by
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity
Butcher, E. C. (1991) · Cell · doi:10.1016/0092-8674(91)90279-8 · Cited by 2,761
Self-citationT-cell receptor cross-linking transiently stimulates adhesiveness through LFA-1
Dustin, M. L., & Springer, T. A. (1989) · Nature · doi:10.1038/341619a0 · Cited by 1,538
Mechanisms That Regulate the Function of the Selectins and Their Ligands
VESTWEBER, D., & BLANKS, J. E. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.181 · Cited by 932
The airway epithelium: soldier in the fight against respiratory viruses
Vareille, M., Kieninger, E., Edwards, M. R., & Regamey, N. (2011) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-10 · Cited by 655
Metadata
- Authors
- Kishimoto, T. K., Jutila, M. A., Berg, E. L., & Butcher, E. C.
- Venue
- Science
- Published
- 1989-09-15
- Volume
- 245
- Issue
- 4923
- Pages
- 1238-1241
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2079096224
- Cited by
- 1,090
- References
- 1
- FWCI
- 13.28
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kishimoto, T. K., Jutila, M. A., Berg, E. L., & Butcher, E. C. (1989). Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors. Science. https://doi.org/10.1126/science.2551036
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
