The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Oncogenic forms of p53 inhibit p53-regulated gene expression
Abstract
Mutant forms of the gene encoding the tumor suppressor p53 are found in numerous human malignancies, but the physiologic function of p53 and the effects of mutations on this function are unknown. The p53 protein binds DNA in a sequence-specific manner and thus may regulate gene transcription. Cotransfection experiments showed that wild-type p53 activated the expression of genes adjacent to a p53 DNA binding site. The level of activation correlated with DNA binding in vitro. Oncogenic forms of p53 lost this activity. Moreover, all mutants inhibited the activity of coexpressed wild-type p53, providing a basis for the selection of such mutants during tumorigenesis.
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Citations
Cites
p53 Mutations in Human Cancers
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Self-citationRecombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
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The p53 tumour suppressor gene
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Germ Line p53 Mutations in a Familial Syndrome of Breast Cancer, Sarcomas, and Other Neoplasms
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Mutations in the p53 gene occur in diverse human tumour types
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Self-citationChromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas
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Self-citationThe p53 proto-oncogene can act as a suppressor of transformation
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Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53
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Self-citation
Cited by
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Self-citationLane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
Toshiyuki, M., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90412-3 · Cited by 4,063
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Self-citationp53 is required for radiation-induced apoptosis in mouse thymocytes
Lowe, S. W., Schmitt, E. M., Smith, S. W., Osborne, B. A., & Jacks, T. (1993) · Nature · doi:10.1038/362847a0 · Cited by 2,864
Metadata
- Authors
- Kern, S., Pietenpol, J., Thiagalingam, S., Seymour, A., Kinzler, K., & Vogelstein, B.
- Venue
- Science
- Published
- 1992-05-08
- Volume
- 256
- Issue
- 5058
- Pages
- 827-830
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2068691401
- Cited by
- 940
- References
- 47
- FWCI
- 39.19
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kern, S., Pietenpol, J., Thiagalingam, S., Seymour, A., Kinzler, K., & Vogelstein, B. (1992). Oncogenic forms of p53 inhibit p53-regulated gene expression. Science. https://doi.org/10.1126/science.1589764
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
