The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor
Abstract
Cells with distinct developmental histories can respond differentially to identical signals, suggesting that signals are interpreted in a fashion that reflects a cell's identity. How this might occur is suggested by the observation that proteins of the homeodomain family, including a newly identified human protein, enhance the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. Interaction with proteins of the serum response factor family may allow homeodomain proteins to specify the transcriptional response to inductive signals. Moreover, because the ability to enhance the binding of serum response factor to DNA resides within the homeodomain but is independent of homeodomain DNA-binding activity, this additional activity of the homeodomain may account for some of the specificity of action of homeodomain proteins in development.
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Metadata
- Authors
- Grueneberg, D. A., Natesan, S., Alexandre, C., & Gilman, M. Z.
- Venue
- Science
- Published
- 1992-08-21
- Volume
- 257
- Issue
- 5073
- Pages
- 1089-1095
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984143972
- Cited by
- 310
- References
- 80
- FWCI
- 15.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Grueneberg, D. A., Natesan, S., Alexandre, C., & Gilman, M. Z. (1992). Human and Drosophila Homeodomain Proteins That Enhance the DNA-Binding Activity of Serum Response Factor. Science. https://doi.org/10.1126/science.257.5073.1089
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
