The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Mutation in the POU-Homeodomain of Pit-1 Responsible for Combined Pituitary Hormone Deficiency
Abstract
Pit-1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals. Mutations in the gene encoding Pit-1 have been found in two dwarf mouse strains displaying hypoplasia of growth hormone, prolactin, and thyroid-stimulating, hormone-secreting cell types in the anterior pituitary. A point mutation in this gene was identified on one allele in a patient with combined pituitary hormone deficiency. Mutant Pit-1 binds DNA normally but acts as a dominant inhibitor of Pit-1 action in the pituitary.
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Cites
Chou, P. Y., & Fasman, G. D. (1974) · Biochemistry · doi:10.1021/bi00699a001 · Cited by 2,172
Hayashizaki, Y., Hiraoka, Y., Endo, Y., Miyai, K., & Matsubara, K. (1989) · The EMBO Journal · doi:10.1002/j.1460-2075.1989.tb08355.x · Cited by 152
Cited by
Achermann, J. C., Ozisik, G., Ito, M., Orun, U. A., Harmanci, K., Gurakan, B., & Jameson, J. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.4.8376 · Cited by 305
Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter
Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G. (1997) · Neuron · doi:10.1016/s0896-6273(00)80353-0 · Cited by 203
Phosphodiesterase 8B Gene Variants Are Associated with Serum TSH Levels and Thyroid Function
Arnaud-Lopez, L., Usala, G., Ceresini, G., Mitchell, B. D., Pilia, M. G., Piras, M. G., Sestu, N., Maschio, A., Busonero, F., Albai, G., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.04.019 · Cited by 139
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
Pfäffle, R., & Klammt, J. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.014 · Cited by 115
Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations
de Magalhães, J. P. (2005) · Ageing Research Reviews · doi:10.1016/j.arr.2004.05.003 · Cited by 54
Metadata
- Authors
- Radovick, S., Nations, M., Du, Y., Berg, L. A., Weintraub, B. D., & Wondisford, F. E.
- Venue
- Science
- Published
- 1992-08-21
- Volume
- 257
- Issue
- 5073
- Pages
- 1115-1118
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981864913
- Cited by
- 449
- References
- 2
- FWCI
- 18.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: A Mutation in the POU-Homeodomain of Pit-1 Responsible for Combined Pituitary Hormone Deficiency. https://app.cochat.ai/papers/10.1126/science.257.5073.1115
- The paper
- Radovick, S., Nations, M., Du, Y., Berg, L. A., Weintraub, B. D., & Wondisford, F. E. (1992). A Mutation in the POU-Homeodomain of Pit-1 Responsible for Combined Pituitary Hormone Deficiency. Science. https://doi.org/10.1126/science.257.5073.1115
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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