Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter
Open accessAbstract
Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. DAT elimination alters the spatial distribution and dramatically reduces the numbers of lactotrophs and somatotrophs in the pituitary. Despite having normal circulating levels of growth hormone and prolactin in blood, hypoplastic glands from DAT-/- mice fail to respond to secretagog stimulation. The effects of DAT deletion on pituitary function result from elevated DA levels that down-regulate the lactotroph D2 DA receptors and depress hypothalamic growth hormone-releasing hormone content. These results reveal an unexpected and important role or DA in the control of developmental events in the pituitary gland and assign a critical role for hypothalamic DA reuptake in regulating these events.
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In these mice, excess dopamine is dispersed by blood flow, reaches the pituitary, and retards growth.
“The excess dopamine is dispersed by blood flow, reaches the pituitary, and retards growth in these animals.”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Bosse et al., 1997
Mice lacking the dopamine transporter show high levels of dopamine in the hypothalamus as well as the striatum.
“Studies of mice (Bosse et al., 1997) that lack the dopamine transporter show that high levels of dopamine occur in the hypothalamus as well as the striatum.”
From Effects of Stimulant Medication on Growth Rates Across 3 Years in the MTA Follow-up (2007) · cites this paper as Bosse et al., 1997
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- Authors
- Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G.
- Affiliations
- Howard Hughes Medical Institute (US)
- Duke Medical Center (US)
- Corresponding author
- Caron, Marc G
- ORCID
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 1997-07
- Volume
- 19
- Issue
- 1
- Pages
- 127-138
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W1990625891
- Cited by
- 203
- References
- 60
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 8
- FWCI
- 10.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Keywords
- dopamine transporter, anterior pituitary hypoplasia, dwarfism, lactotrophs, somatotrophs, growth hormone, prolactin, dopamine D2 receptor, growth hormone-releasing hormone, hypothalamus, lactation, pituitary development, dopamine reuptake
- MeSH terms
- Animals, Carrier Proteins, Dopamine, Dwarfism, Hypothalamus, Membrane Glycoproteins, Mice, Mutant Strains, Nerve Tissue Proteins, Pituitary Diseases, Pituitary Gland, Anterior, In Situ Hybridization, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice
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