Cited by 203Hypothalamic control of reproductive hormonesGrowth Hormone and Insulin-like Growth FactorsPituitary Gland Disorders and Treatments

Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter

Open access
Bossé, Roger, Fumagalli, Fabio, Jaber, Mohamed, Giros, Bruno, Gainetdinov, Raul R, Wetsel, William C, Missale, Cristina, Caron, Marc G·1997·Neuron

Abstract

Deletion of the dopamine transporter (DAT) results in increased dopaminergic tone, anterior pituitary hypoplasia, dwarfism, and an inability to lactate. DAT elimination alters the spatial distribution and dramatically reduces the numbers of lactotrophs and somatotrophs in the pituitary. Despite having normal circulating levels of growth hormone and prolactin in blood, hypoplastic glands from DAT-/- mice fail to respond to secretagog stimulation. The effects of DAT deletion on pituitary function result from elevated DA levels that down-regulate the lactotroph D2 DA receptors and depress hypothalamic growth hormone-releasing hormone content. These results reveal an unexpected and important role or DA in the control of developmental events in the pituitary gland and assign a critical role for hypothalamic DA reuptake in regulating these events.

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Crossref · 10.1016/s0896-6273(00)80353-0

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Authors
Bossé, R., Fumagalli, F., Jaber, M., Giros, B., Gainetdinov, R. R., Wetsel, W. C., Missale, C., & Caron, M. G.
Affiliations
  • Howard Hughes Medical Institute (US)
  • Duke Medical Center (US)
Corresponding author
Caron, Marc G
Venue
Neuron
Publisher
Elsevier BV
Published
1997-07
Volume
19
Issue
1
Pages
127-138
ISSN
0896-6273 (ISSN-L)
OpenAlex
W1990625891
Cited by
203
References
60
Citations by year
2026: 2 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 4 · 2014: 5 · 2013: 9 · 2012: 8
FWCI
10.42
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords
dopamine transporter, anterior pituitary hypoplasia, dwarfism, lactotrophs, somatotrophs, growth hormone, prolactin, dopamine D2 receptor, growth hormone-releasing hormone, hypothalamus, lactation, pituitary development, dopamine reuptake
MeSH terms
Animals, Carrier Proteins, Dopamine, Dwarfism, Hypothalamus, Membrane Glycoproteins, Mice, Mutant Strains, Nerve Tissue Proteins, Pituitary Diseases, Pituitary Gland, Anterior, In Situ Hybridization, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins, Mice

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