The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene
Abstract
The active hormonal form of vitamin D 3 , 1,25-dihydroxyvitamin D 3 [1,25(OH), which regulates cellular replication and function in many tissues and has a role in bone and calcium homeostasis, acts through a hormone receptor homologous with other steroid and thyroid hormone receptors. A 1,25(OH) 2 D 3 -responsive element (VDRE), which is within the promoter for osteocalcin [a bone protein induced by 1,25(OH) 2 D 3 ] is unresponsive to other steroid hormones, can function in a heterologous promoter, and contains a doubly palindromic DNA sequence (TT GGTGA C TCACC G GGTGA AC; -513 to -493 bp), with nucleotide sequence homology to other hormone responsive elements. The potent glucocorticoid repression of 1,25(OH) 2 D 3 induction and of basal activity of this promoter acts through a region between -196 and +34 bp, distinct from the VDRE.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
Gorman, C. M., Moffat, L. F., & Howard, B. H. (1982) · Molecular and Cellular Biology · doi:10.1128/mcb.2.9.1044 · Cited by 7,830
The Steroid and Thyroid Hormone Receptor Superfamily
Evans, R. M. (1988) · Science · doi:10.1126/science.3283939 · Cited by 7,439
STEROID RECEPTOR REGULATED TRANSCRIPTION OF SPECIFIC GENES AND GENE NETWORKS
Yamamoto, K. R. (1985) · Annual Review of Genetics · doi:10.1146/annurev.ge.19.120185.001233 · Cited by 1,872
Transcriptional Control Signals of a Eukaryotic Protein-Coding Gene
McKnight, S. L., & Kingsbury, R. (1982) · Science · doi:10.1126/science.6283634 · Cited by 1,318
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.
Wigler, M., Pellicer, A., Silverstein, S., Axel, R., Urlaub, G., & Chasin, L. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.3.1373 · Cited by 1,279
Evidence of Estrogen Receptors in Normal Human Osteoblast-Like Cells
Eriksen, E. F., Colvard, D. S., Berg, N. J., Graham, M. L., Mann, K. G., Spelsberg, T. C., & Riggs, B. L. (1988) · Science · doi:10.1126/science.3388021 · Cited by 1,229
Cloning and expression of full-length cDNA encoding human vitamin D receptor.
Baker, A. R., McDonnell, D. P., Hughes, M., Crisp, T. M., Mangelsdorf, D. J., Haussler, M. R., Pike, J. W., Shine, J., & O'Malley, B. W. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.10.3294 · Cited by 959
Self-citationEstrogen Binding, Receptor mRNA, and Biologic Response in Osteoblast-Like Osteosarcoma Cells
Komm, B. S., Terpening, C. M., Benz, D. J., Graeme, K. A., Gallegos, A., Korc, M., Greene, G. L., O'Malley, B. W., & Haussler, M. R. (1988) · Science · doi:10.1126/science.3164526 · Cited by 812
Characterization of a gamma-carboxyglutamic acid-containing protein from bone.
Price, P. A., Otsuka, A. A., Poser, J. W., Kristaponis, J., & Raman, N. (1976) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.73.5.1447 · Cited by 787
Price, P. A., Parthemore, J. G., & Deftos, L. J. (1980) · Journal of Clinical Investigation · doi:10.1172/jci109954 · Cited by 657
Cited by
Prediction of bone density from vitamin D receptor alleles
Morrison, N. A., Qi, J. C., Tokita, A., Kelly, P. J., Crofts, L., Nguyen, T. V., Sambrook, P. N., & Eisman, J. A. (1994) · Nature · doi:10.1038/367284a0 · Cited by 1,919
Self-citationDifferential Recognition of Target Genes by Nuclear Receptor Monomers, Dimers, and Heterodimers*
GLASS, C. K. (1994) · Endocrine Reviews · doi:10.1210/edrv-15-3-391 · Cited by 829
Morrison, N. A., Yeoman, R., Kelly, P. J., & Eisman, J. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.15.6665 · Cited by 601
Self-citationMINIREVIEW: Interactions Among a Subfamily of Nuclear Hormone Receptors: The Regulatory Zipper Model
Forman, B. M., & Samuels, H. H. (1990) · Molecular Endocrinology · doi:10.1210/mend-4-9-1293 · Cited by 414
Nagpal, S., Friant, S., Nakshatri, H., & Chambon, P. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05889.x · Cited by 302
Metadata
- Authors
- Morrison, N. A., Shine, J., Fragonas, J.-C., Verkest, V., McMenemy, M. L., & Eisman, J. A.
- Venue
- Science
- Published
- 1989-12
- Volume
- 246
- Issue
- 4934
- Pages
- 1158-1161
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082703532
- Cited by
- 408
- References
- 37
- FWCI
- 23.15
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: 1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene. https://app.cochat.ai/papers/10.1126/science.2588000
- The paper
- Morrison, N. A., Shine, J., Fragonas, J.-C., Verkest, V., McMenemy, M. L., & Eisman, J. A. (1989). 1,25-Dihydroxyvitamin D-Responsive Element and Glucocorticoid Repression in the Osteocalcin Gene. Science. https://doi.org/10.1126/science.2588000
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
