The DOI matches its Crossref record; 93 of the 93 references it cites were found in a registry or an index.
Functions of Sphingolipids and Sphingolipid Breakdown Products in Cellular Regulation
Abstract
The discovery that breakdown products of cellular sphingolipids are biologically active has generated interest in the role of these molecules in cell physiology and pathology. Sphingolipid breakdown products, sphingosine and lysosphingolipids, inhibit protein kinase C, a pivotal enzyme in cell regulation and signal transduction. Sphingolipids and lysosphingolipids affect significant cellular responses and exhibit antitumor promoter activities in various mammalian cells. These molecules may function as endogenous modulators of cell function and possibly as second messengers.
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Citations
Cites
Studies and Perspectives of Protein Kinase C
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Inositol trisphosphate and diacylglycerol as second messengers
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Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects
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Phorbol diester receptor copurifies with protein kinase C.
Niedel, J. E., Kuhn, L. J., & Vandenbark, G. R. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.36 · Cited by 1,169
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Self-citationStructural and Functional Roles of Glycosyl-Phosphatidylinositol in Membranes
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Cited by
Programmed Cell Death Induced by Ceramide
Obeid, L. M., Linardic, C. M., Karolak, L. A., & Hannun, Y. A. (1993) · Science · doi:10.1126/science.8456305 · Cited by 1,794
Self-citationTNF receptor subtype signalling: Differences and cellular consequences
MacEwan, D. J. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00262-5 · Cited by 610
Lysosomal disorders: From storage to cellular damage
Ballabio, A., & Gieselmann, V. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.001 · Cited by 571
Mattie, M., Brooker, G., & Spiegel, S. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)41846-1 · Cited by 273
Ballou, L. R., Chao, C. P., Holness, M. A., Barker, S. C., & Raghow, R. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)88663-5 · Cited by 272
Metadata
- Authors
- Hannun, Y. A., & Bell, R. M.
- Venue
- Science
- Published
- 1989-01-27
- Volume
- 243
- Issue
- 4890
- Pages
- 500-507
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2061574494
- Cited by
- 1,251
- References
- 93
- FWCI
- 35.83
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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