The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Genetic Control of Differentiation of the Caenorhabditis elegans Touch Receptor Neurons
Abstract
The genetic control of neuronal differentiation has been studied by examining mutations that affect the development and function of the six touch receptor neurons of the nematode Caenorhabditis elegans . By screening for touch-insensitive mutants, it has been possible to identify 18 genes (represented by 417 mutations) that are required at various stages in the developmental program for touch cell differentiation. Two of the genes are needed for the generation of precursors in the touch cell lineages; without the precursors, touch cells are not made. A third gene, mec-3 , specifies the differentiation of the touch cells, probably by acting as a transcription factor. The remaining 15 genes are likely targets of mec-3 action; mutants defective in these genes have nonfunctioning, yet differentiated, touch cells. Some of these latter genes are needed for the formation of cell-specific components of the touch cells, such as a set of microtubules that are only found in these cells. The study of the touch genes should help us understand how touch cell fate is determined, how microtubule form is specified, and, perhaps, how mechanical stimuli are transduced.
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
The embryonic cell lineage of the nematode Caenorhabditis elegans
Sulston, J. E., Schierenberg, E., White, J. G., & Thomson, J. N. (1983) · Developmental Biology · doi:10.1016/0012-1606(83)90201-4 · Cited by 4,199
The neural circuit for touch sensitivity in Caenorhabditis elegans
Chalfie, M., Sulston, J., White, J., Southgate, E., Thomson, J., & Brenner, S. (1985) · The Journal of Neuroscience · doi:10.1523/jneurosci.05-04-00956.1985 · Cited by 1,093
Self-citation
Cited by
MEC-17 is an α-tubulin acetyltransferase
Akella, J. S., Wloga, D., Kim, J., Starostina, N. G., Lyons-Abbott, S., Morrissette, N. S., Dougan, S. T., Kipreos, E. T., & Gaertig, J. (2010) · Nature · doi:10.1038/nature09324 · Cited by 489
Forward genetic analysis of visual behavior in zebrafish
Muto, A., Orger, M. B., Wehman, A. M., Smear, M. C., Kay, J. N., Page-McCaw, P. S., Gahtan, E., Xiao, T., Nevin, L. M., Gosse, N. J., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010066 · Cited by 321
Hall, D., & Russell, R. (1991) · The Journal of Neuroscience · doi:10.1523/jneurosci.11-01-00001.1991 · Cited by 268
Integration of mechanosensory stimuli in Caenorhabditis elegans
Wicks, Sr., & Rankin, C. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-03-02434.1995 · Cited by 240
Thinking about genetic redundancy
Thomas, J. H. (1993) · Trends in Genetics · doi:10.1016/0168-9525(93)90140-d · Cited by 239
Metadata
- Authors
- Chalfie, M., & Au, M.
- Venue
- Science
- Published
- 1989-02-24
- Volume
- 243
- Issue
- 4894
- Pages
- 1027-1033
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016407412
- Cited by
- 345
- References
- 3
- FWCI
- 4.09
- Type
- journal article
- Language
- en
- Open access
- closed
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