The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
The Role of Somatic Hypermutation in the Generation of Antibody Diversity
Abstract
The immune system is capable of establishing an enormous repertoire of antibodies before its first contact with antigen. Most antibodies that express germ-line sequences are of relatively low affinity. Once antigen enters the system, it stimulates a somatic mutational mechanism that generates antibodies of higher affinity and selects for the expression of those antibodies to produce a more effective immune response. The details of the mechanism and regulation of somatic hypermutation remain to be elucidated.
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Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
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The Role of Helper T Cell Products in Mouse B Cell Differentiation and Isotype Regulation
Coffman, R. L., Seymour, B. W. P., Lebman, D. A., Hiraki, D. D., Christiansen, J. A., Shrader, B., Cherwinski, H. M., Savelkoul, H. F. J., Finkelman, F. D., Bond, M. W., et al. (1988) · Immunological Reviews · doi:10.1111/j.1600-065x.1988.tb00739.x · Cited by 755
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Development of the Primary Antibody Repertoire
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Cited by
The Function of Allergy: Immunological Defense Against Toxins
Profet, M. (1991) · The Quarterly Review of Biology · doi:10.1086/417049 · Cited by 155
Metadata
- Authors
- French, D. L., Laskov, R., & Scharff, M. D.
- Venue
- Science
- Published
- 1989-06-09
- Volume
- 244
- Issue
- 4909
- Pages
- 1152-1157
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984248194
- Cited by
- 301
- References
- 67
- FWCI
- 9.21
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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