The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Development of the Primary Antibody Repertoire
Abstract
The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.
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Citations
Cites
Somatic generation of antibody diversity
Tonegawa, S. (1983) · Nature · doi:10.1038/302575a0 · Cited by 4,005
Cited by
Su, X.-Z., Heatwole, V. M., Wertheimer, S. P., Guinet, F., Herrfeldt, J. A., Peterson, D. S., Ravetch, J. A., & Wellems, T. E. (1995) · Cell · doi:10.1016/0092-8674(95)90055-1 · Cited by 1,219
Gu, H., Zou, Y.-R., & Rajewsky, K. (1993) · Cell · doi:10.1016/0092-8674(93)90644-6 · Cited by 989
BAIN, G. (1994) · Cell · doi:10.1016/0092-8674(94)90077-9 · Cited by 635
Protein Design by Directed Evolution
Jäckel, C., Kast, P., & Hilvert, D. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125832 · Cited by 409
Ehlich, A. (1993) · Cell · doi:10.1016/0092-8674(93)90398-a · Cited by 310
Metadata
- Authors
- Alt, F. W., Blackwell, T. K., & Yancopoulos, G. D.
- Venue
- Science
- Published
- 1987-11-20
- Volume
- 238
- Issue
- 4830
- Pages
- 1079-1087
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024208188
- Cited by
- 615
- References
- 1
- FWCI
- 22.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Development of the Primary Antibody Repertoire. https://app.cochat.ai/papers/10.1126/science.3317825
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- Alt, F. W., Blackwell, T. K., & Yancopoulos, G. D. (1987). Development of the Primary Antibody Repertoire. Science. https://doi.org/10.1126/science.3317825
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
