The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs
Abstract
Phencyclidine (PCP), a dissociative anesthetic and widely abused psychotomimetic drug, and MK-801, a potent PCP receptor ligand, have neuroprotective properties stemming from their ability to antagonize the excitotoxic actions of endogenous excitatory amino acids such as glutamate and aspartate. There is growing interest in the potential application of these compounds in the treatment of neurological disorders. However, there is an apparent neurotoxic effect of PCP and related agents (MK-801, tiletamine, and ketamine), which has heretofore been overlooked: these drugs induce acute pathomorphological changes in specific populations of brain neurons when administered subcutaneously to adult rats in relatively low doses. These findings raise new questions regarding the safety of these agents in the clinical management of neurodegenerative diseases and reinforce concerns about the potential risks associated with illicit use of PCP.
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The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist.
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Quantitative Cytoarchitectural Studies of the Cerebral Cortex of Schizophrenics
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Non-competitive antagonists of excitatory amino acid receptors
Kemp, J. A., Foster, A. C., & Wong, E. H. F. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90176-7 · Cited by 498
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GLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS: An Electron Microscopic Study
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Self-citationSpecific [3H]phencyclidine binding in rat central nervous system.
Zukin, S. R., & Zukin, R. S. (1979) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.76.10.5372 · Cited by 380
Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats
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Self-citationInteraction of phencyclidine ("angel dust") with a specific receptor in rat brain membranes.
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Cited by
Krystal, J. H. (1994) · Archives of General Psychiatry · doi:10.1001/archpsyc.1994.03950030035004 · Cited by 3,330
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Moghaddam, B., Adams, B., Verma, A., & Daly, D. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02921.1997 · Cited by 1,793
Metabolic reduction in the posterior cingulate cortex in very early Alzheimer's disease
Minoshima, S., Giordani, B., Berent, S., Frey, K. A., Foster, N. L., & Kuhl, D. E. (1997) · Annals of Neurology · doi:10.1002/ana.410420114 · Cited by 1,802
Glutamate receptor dysfunction and schizophrenia
Olney, J. W. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950240016004 · Cited by 1,685
Self-citation
Metadata
- Authors
- Olney, J. W., Labruyere, J., & Price, M. T.
- Venue
- Science
- Published
- 1989-06-16
- Volume
- 244
- Issue
- 4910
- Pages
- 1360-1362
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1981234599
- Cited by
- 1,237
- References
- 21
- FWCI
- 11.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Olney, J. W., Labruyere, J., & Price, M. T. (1989). Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs. Science. https://doi.org/10.1126/science.2660263
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
