The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats
Abstract
Administration of pilocarpine or physostigmine to rats treated with lithium chloride produced sustained limbic seizures, widespread brain damage, and increased concentrations of D- myo -inositol-1-phosphate (a metabolite of the phosphoinositides, lipids involved in membrane receptor function) in the brain. The syndrome was preventable with atropine. The physostigmine doses and concentrations of blood lithium that caused the syndrome are similar to those considered appropriate for psychiatric chemotherapy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Inositol phospholipids and cell surface receptor function
Michell, R. H. (1975) · Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes · doi:10.1016/0304-4157(75)90017-9 · Cited by 2,470
Hallcher, L. M., & Sherman, W. R. (1980) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)70391-3 · Cited by 1,101
Self-citationOlney, J. W., Ho, O., & Rhee, V. (1971) · Experimental Brain Research · doi:10.1007/bf00234911 · Cited by 802
Self-citationGLUTAMATE-INDUCED NEURONAL NECROSIS IN THE INFANT MOUSE HYPOTHALAMUS: An Electron Microscopic Study
OLNEY, J. W. (1971) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-197101000-00008 · Cited by 415
Self-citationLithium Carbonate, Haloperidol, and Irreversible Brain Damage
Cohen, W. J. (1974) · JAMA · doi:10.1001/jama.1974.03240090023018 · Cited by 394
Acute dendrotoxic changes in the hippocampus of kainate treated rats
Olney, J. W., Fuller, T., & De Gubareff, T. (1979) · Brain Research · doi:10.1016/0006-8993(79)90872-2 · Cited by 300
Self-citationSherman, W. R., Leavitt, A. L., Honchar, M. P., Hallcher, L. M., & Phillips, B. E. (1981) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1981.tb10819.x · Cited by 270
Self-citationIncreased brain myo-inositol 1-phosphate in lithium-treated rats
Allison, J. H., Blisner, M. E., Holland, W. H., Hipps, P. P., & Sherman, W. R. (1976) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(76)90839-1 · Cited by 250
Self-citationPHOSPHOLIPIDS IN SYNAPTIC FUNCTION
Hawthorne, J. N., & Pickard, M. R. (1979) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1979.tb04503.x · Cited by 233
Cited by
Pathological Changes Induced in Cerebrocortical Neurons by Phencyclidine and Related Drugs
Olney, J. W., Labruyere, J., & Price, M. T. (1989) · Science · doi:10.1126/science.2660263 · Cited by 1,237
Self-citationThe pilocarpine model of temporal lobe epilepsy
Curia, G., Longo, D., Biagini, G., Jones, R. S. G., & Avoli, M. (2008) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2008.04.019 · Cited by 1,041
Neural and developmental actions of lithium: A unifying hypothesis
Berridge, M. J., Downes, C. P., & Hanley, M. R. (1989) · Cell · doi:10.1016/0092-8674(89)90026-3 · Cited by 1,014
Bouilleret, V, Ridoux, V, Depaulis, A., Marescaux, C., Nehlig, A., & Le Gal La Salle, G. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00401-1 · Cited by 428
Kapur, J., & Macdonald, R. L. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-19-07532.1997 · Cited by 427
Metadata
- Authors
- Honchar, M. P., Olney, J. W., & Sherman, W. R.
- Venue
- Science
- Published
- 1983-04-15
- Volume
- 220
- Issue
- 4594
- Pages
- 323-325
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2009304543
- Cited by
- 366
- References
- 27
- FWCI
- 14.58
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats. https://app.cochat.ai/papers/10.1126/science.6301005
- The paper
- Honchar, M. P., Olney, J. W., & Sherman, W. R. (1983). Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats. Science. https://doi.org/10.1126/science.6301005
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
