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Mutants of Pertussis Toxin Suitable for Vaccine Development
Abstract
Immunization with chemically detoxified pertussis toxin can prevent severe whooping cough with an efficacy similar to that of the cellular pertussis vaccine, which normally gives unwanted side effects. To avoid the reversion to toxicity and the loss of immunogenicity that may follow chemical treatment of pertussis toxin, inactive toxins were constructed by genetic manipulation. A number of genetically engineered alleles of the pertussis toxin genes, constructed by replacing either one or two key amino acids within the enzymatically active S1 subunit, were introduced into the chromosome of strains of Bordetella pertussis , B. parapertussis , and B. bronchiseptica . These strains produce mutant pertussis toxin molecules that are nontoxic and immunogenic and that protect mice from the intracerebral challenge with virulent Bordetella pertussis. Such molecules are ideal for the development of new and safer vaccines against whooping cough.
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Cited by
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Huo, Y., Weber, C., Forlow, S. B., Sperandio, M., Thatte, J., Mack, M., Jung, S., Littman, D. R., & Ley, K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12877 · Cited by 266
Piccio, L., Rossi, B., Scarpini, E., Laudanna, C., Giagulli, C., Issekutz, A. C., Vestweber, D., Butcher, E. C., & Constantin, G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1940 · Cited by 245
Metadata
- Authors
- Pizza, M., Covacci, A., Bartoloni, A., Perugini, M., Nencioni, L., De Magistris, M. T., Villa, L., Nucci, D., Manetti, R., Bugnoli, M., Giovannoni, F., Olivieri, R., Barbieri, J. T., Sato, H., & Rappuoli, R.
- Venue
- Science
- Published
- 1989-10-27
- Volume
- 246
- Issue
- 4929
- Pages
- 497-500
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2047034219
- Cited by
- 312
- References
- 0
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- closed
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- Pizza, M., Covacci, A., Bartoloni, A., Perugini, M., Nencioni, L., De Magistris, M. T., Villa, L., Nucci, D., Manetti, R., Bugnoli, M., Giovannoni, F., Olivieri, R., Barbieri, J. T., Sato, H., & Rappuoli, R. (1989). Mutants of Pertussis Toxin Suitable for Vaccine Development. Science. https://doi.org/10.1126/science.2683073
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