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Checkpoints: Controls That Ensure the Order of Cell Cycle Events

Hartwell, Leland H., Weinert, Ted A.·1989·Science
DOI 10.1126/science.2683079
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Abstract

The events of the cell cycle of most organisms are ordered into dependent pathways in which the initiation of late events is dependent on the completion of early events. In eukaryotes, for example, mitosis is dependent on the completion of DNA synthesis. Some dependencies can be relieved by mutation (mitosis may then occur before completion of DNA synthesis), suggesting that the dependency is due to a control mechanism and not an intrinsic feature of the events themselves. Control mechanisms enforcing dependency in the cell cycle are here called checkpoints. Elimination of checkpoints may result in cell death, infidelity in the distribution of chromosomes or other organelles, or increased susceptibility to environmental perturbations such as DNA damaging agents. It appears that some checkpoints are eliminated during the early embryonic development of some organisms; this fact may pose special problems for the fidelity of embryonic cell division.

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Metadata

Authors
Hartwell, L. H., & Weinert, T. A.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1989-11-03
Volume
246
Issue
4930
Pages
629-634
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.2683079
OpenAlex
W2004008931
Cited by
3,021
References
0
FWCI
29.39
Type
journal article
Language
en
Open access
closed

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Hartwell, L. H., & Weinert, T. A. (1989). Checkpoints: Controls That Ensure the Order of Cell Cycle Events. Science. https://doi.org/10.1126/science.2683079

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