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Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15
Abstract
Cdc2 is the cyclin-dependent kinase that controls entry of cells into mitosis. Phosphorylation of Cdc2 on threonine-14 and tyrosine-15 inhibits the activity of the enzyme and prevents premature initiation of mitosis. Although Wee1 has been identified as the kinase that phosphorylates tyrosine-15 in various organisms, the threonine-14-specific kinase has not been isolated. A complementary DNA was cloned from Xenopus that encodes Myt1, a member of the Wee1 family that was discovered to phosphorylate Cdc2 efficiently on both threonine-14 and tyrosine-15. Myt1 is a membrane-associated protein that contains a putative transmembrane segment. Immunodepletion studies suggested that Myt1 is the predominant threonine-14-specific kinase in Xenopus egg extracts. Myt1 activity is highly regulated during the cell cycle, suggesting that this relative of Wee1 plays a role in mitotic control.
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Metadata
- Authors
- Mueller, P. R., Coleman, T. R., Kumagai, A., & Dunphy, W. G.
- Venue
- Science
- Published
- 1995-10-06
- Volume
- 270
- Issue
- 5233
- Pages
- 86-90
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2003381961
- Cited by
- 695
- References
- 0
- FWCI
- 12.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mueller, P. R., Coleman, T. R., Kumagai, A., & Dunphy, W. G. (1995). Myt1: A Membrane-Associated Inhibitory Kinase That Phosphorylates Cdc2 on Both Threonine-14 and Tyrosine-15. Science. https://doi.org/10.1126/science.270.5233.86
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