The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Relaxation of Arterial Smooth Muscle by Calcium Sparks
Abstract
Local increases in intracellular calcium ion concentration ([Ca 2+ ] i ) resulting from activation of the ryanodine-sensitive calcium-release channel in the sarcoplasmic reticulum (SR) of smooth muscle cause arterial dilation. Ryanodine-sensitive, spontaneous local increases in [Ca 2+ ] i (Ca 2+ sparks) from the SR were observed just under the surface membrane of single smooth muscle cells from myogenic cerebral arteries. Ryanodine and thapsigargin inhibited Ca 2+ sparks and Ca 2+ -dependent potassium (K Ca ) currents, suggesting that Ca 2+ sparks activate K Ca channels. Furthermore, K Ca channels activated by Ca 2+ sparks appeared to hyperpolarize and dilate pressurized myogenic arteries because ryanodine and thapsigargin depolarized and constricted these arteries to an extent similar to that produced by blockers of K Ca channels. Ca 2+ sparks indirectly cause vasodilation through activation of K Ca channels, but have little direct effect on spatially averaged [Ca 2+ ] i , which regulates contraction.
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Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436
Cited by
Calcium-activated potassium channels
Vergara, C., Latorre, R., Marrion, N. V., & Adelman, J. P. (1998) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(98)80056-1 · Cited by 954
Davis, M. J., Earley, S., Li, Y.-S., & Chien, S. (2023) · Physiological Reviews · doi:10.1152/physrev.00053.2021 · Cited by 273
Minding the calcium store: Ryanodine receptor activation as a convergent mechanism of PCB toxicity
Pessah, I. N., Cherednichenko, G., & Lein, P. J. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.10.009 · Cited by 231
Photolysis of Caged Calcium in Femtoliter Volumes Using Two-Photon Excitation
Brown, E. B., Shear, J. B., Adams, S. R., Tsien, R. Y., & Webb, W. W. (1999) · Biophysical Journal · doi:10.1016/s0006-3495(99)77217-6 · Cited by 181
Ion channel networks in the control of cerebral blood flow
Longden, T. A., Hill-Eubanks, D. C., & Nelson, M. T. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x15616138 · Cited by 137
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Metadata
- Authors
- Nelson, M. T., Cheng, H., Rubart, M., Santana, L. F., Bonev, A. D., Knot, H. J., & Lederer, W. J.
- Venue
- Science
- Published
- 1995-10-27
- Volume
- 270
- Issue
- 5236
- Pages
- 633-637
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1965021019
- Cited by
- 1,396
- References
- 1
- FWCI
- 17.88
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
