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Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege
Open accessAbstract
The eye is a privileged site that cannot tolerate destructive inflammatory responses. Inflammatory cells entering the anterior chamber of the eye in response to viral infection underwent apoptosis that was dependent on Fas (CD95)-Fas ligand (FasL) and produced no tissue damage. In contrast, viral infection in gld mice, which lack functional FasL, resulted in an inflammation and invasion of ocular tissue without apoptosis. Fas-positive but not Fas-negative tumor cells were killed by apoptosis when placed within isolated anterior segments of the eyes of normal but not FasL-negative mice. FasL messenger RNA and protein were detectable in the eye. Thus, Fas-FasL interactions appear to be an important mechanism for the maintenance of immune privilege.
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Citations
Cites
Immunoregulatory mechanisms of the eye
Streilein, J. W., Wilbanks, G. A., & Cousins, S. W. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90253-h · Cited by 157
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Dong, H., Strome, S. E., Salomao, D. R., Tamura, H., Hirano, F., Flies, D. B., Roche, P. C., Lu, J., Zhu, G., Tamada, K., et al. (2002) · Nature Medicine · doi:10.1038/nm730 · Cited by 5,025
Nagata, S. (1997) · Cell · doi:10.1016/s0092-8674(00)81874-7 · Cited by 4,938
Signalling pathways of the TNF superfamily: a double-edged sword
Aggarwal, B. B. (2003) · Nature Reviews Immunology · doi:10.1038/nri1184 · Cited by 2,793
Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo.
Walczak, H., Miller, R. E., Ariail, K., Gliniak, B., Griffith, T. S., Kubin, M., Chin, W., Jones, J., Woodward, A., Le, T., et al. (1999) · Nature Medicine · doi:10.1038/5517 · Cited by 2,497
Self-citationThe many roles of FAS receptor signaling in the immune system
Strasser, A., Jost, P. J., & Nagata, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.001 · Cited by 968
Metadata
- Authors
- Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A.
- Venue
- Science
- Published
- 1995-11-17
- Volume
- 270
- Issue
- 5239
- Pages
- 1189-1192
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978018492
- Cited by
- 2,005
- References
- 1
- FWCI
- 42.28
- Type
- journal article
- Language
- en
- Open access
- green
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- Griffith, T. S., Brunner, T., Fletcher, S. M., Green, D. R., & Ferguson, T. A. (1995). Fas Ligand-Induced Apoptosis as a Mechanism of Immune Privilege. Science. https://doi.org/10.1126/science.270.5239.1189
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
