The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
A Human Telomeric Protein
Abstract
Telomeres are multifunctional elements that shield chromosome ends from degradation and end-to-end fusions, prevent activation of DNA damage checkpoints, and modulate the maintenance of telomeric DNA by telomerase. A major protein component of human telomeres has been identified and cloned. This factor, TRF, contains one Myb-type DNA-binding repeat and an amino-terminal acidic domain. Immunofluorescent labeling shows that TRF specifically colocalizes with telomeric DNA in human interphase cells and is located at chromosome ends during metaphase. The presence of TRF along the telomeric TTAGGG repeat array demonstrates that human telomeres form a specialized nucleoprotein complex.
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Basic local alignment search tool
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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer
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Telomeres shorten during ageing of human fibroblasts
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The RNA Component of Human Telomerase
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Cited by
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056
Mammalian Telomeres End in a Large Duplex Loop
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How Shelterin Protects Mammalian Telomeres
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Self-citationTRF2 Protects Human Telomeres from End-to-End Fusions
van Steensel, B., Smogorzewska, A., & de Lange, T. (1998) · Cell · doi:10.1016/s0092-8674(00)80932-0 · Cited by 1,709
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219
Metadata
- Authors
- Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., & de Lange, T.
- Venue
- Science
- Published
- 1995-12-08
- Volume
- 270
- Issue
- 5242
- Pages
- 1663-1667
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2050674095
- Cited by
- 694
- References
- 12
- FWCI
- 23.01
- Type
- journal article
- Language
- en
- Open access
- closed
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- Chong, L., van Steensel, B., Broccoli, D., Erdjument-Bromage, H., Hanish, J., Tempst, P., & de Lange, T. (1995). A Human Telomeric Protein. Science. https://doi.org/10.1126/science.270.5242.1663
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
