The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex
Abstract
The crystal structure of a nucleic acid triplex reveals a helix, designated P-form, that differs from previously reported nucleic acid structures. The triplex consists of one polypurine DNA strand complexed to a polypyrimidine hairpin peptide nucleic acid (PNA) and was successfully designed to promote Watson-Crick and Hoogsteen base pairing. The P-form helix is underwound, with a base tilt similar to B-form DNA. The bases are displaced from the helix axis even more than in A-form DNA. Hydrogen bonds between the DNA backbone and the Hoogsteen PNA backbone explain the observation that polypyrimidine PNA sequences form highly stable 2:1 PNA-DNA complexes. This structure expands the number of known stable helical forms that nucleic acids can adopt.
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Cites
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
PNA hybridizes to complementary oligonucleotides obeying the Watson–Crick hydrogen-bonding rules
Egholm, M., Buchardt, O., Christensen, L., Behrens, C., Freier, S. M., Driver, D. A., Berg, R. H., Kim, S. K., Norden, B., & Nielsen, P. E. (1993) · Nature · doi:10.1038/365566a0 · Cited by 2,079
Cited by
Peptide nucleic acid (PNA): its medical and biotechnical applications and promise for the future
Ray, A., & Nordén, B. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.9.1041 · Cited by 416
Peptide Nucleic Acid. A Molecule with Two Identities
Nielsen, P. E. (1999) · Accounts of Chemical Research · doi:10.1021/ar980010t · Cited by 380
Colominas, C., Luque, F. J., & Orozco, M. (1996) · Journal of the American Chemical Society · doi:10.1021/ja954293l · Cited by 332
Metadata
- Authors
- Betts, L., Josey, J. A., Veal, J. M., & Jordan, S. R.
- Venue
- Science
- Published
- 1995-12-15
- Volume
- 270
- Issue
- 5243
- Pages
- 1838-1841
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2017033748
- Cited by
- 298
- References
- 2
- FWCI
- 7.11
- Type
- journal article
- Language
- en
- Open access
- closed
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- Betts, L., Josey, J. A., Veal, J. M., & Jordan, S. R. (1995). A Nucleic Acid Triple Helix Formed by a Peptide Nucleic Acid-DNA Complex. Science. https://doi.org/10.1126/science.270.5243.1838
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