The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Cell Killing by the Drosophila Gene reaper
Abstract
The reaper gene ( rpr ) is important for the activation of apoptosis in Drosophila . To investigate whether rpr expression is sufficient to induce apoptosis, transgenic flies were generated that express rpr complementary DNA or the rpr open reading frame in cells that normally live. Transcription of rpr from a heat-inducible promoter rapidly caused widespread ectopic apoptosis and organismal death. Ectopic overexpression of rpr in the developing retina resulted in eye ablation. The occurrence of cell death was highly sensitive to the dosage of the transgene. Because cell death induced by the protein encoded by rpr (RPR) could be blocked by the baculovirus p35 protein, RPR appears to activate a death program mediated by a ced-3 /ICE (interleukin-1 converting enzyme)-like protease.
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Cites
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.
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Mechanisms and Genes of Cellular Suicide
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Self-citationExpression of baculovirus P35 prevents cell death in Drosophila
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Self-citationProgrammed cell death during Drosophila embryogenesis
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Self-citationThe head involution defective gene of Drosophila melanogaster functions in programmed cell death.
Grether, M. E., Abrams, J. M., Agapite, J., White, K., & Steller, H. (1995) · Genes & Development · doi:10.1101/gad.9.14.1694 · Cited by 699
Self-citationInhibition of ICE Family Proteases by Baculovirus Antiapoptotic Protein p35
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Cited by
Muzio, M., Chinnaiyan, A. M., Kischkel, F. C., O'Rourke, K., Shevchenko, A., Ni, J., Scaffidi, C., Bretz, J. D., Zhang, M., Gentz, R., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81266-0 · Cited by 3,046
Programmed Cell Death in Animal Development and Disease
Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915
Self-citationHippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
Udan, R. S., Kango-Singh, M., Nolo, R., Tao, C., & Halder, G. (2003) · Nature Cell Biology · doi:10.1038/ncb1050 · Cited by 747
Expanded Polyglutamine Protein Forms Nuclear Inclusions and Causes Neural Degeneration in Drosophila
Warrick, J. M., Paulson, H. L., Gray-Board, G. L., Bui, Q. T., Fischbeck, K. H., Pittman, R. N., & Bonini, N. M. (1998) · Cell · doi:10.1016/s0092-8674(00)81200-3 · Cited by 668
Drosophila p53 Binds a Damage Response Element at the reaper Locus
Brodsky, M. H., Nordstrom, W., Tsang, G., Kwan, E., Rubin, G. M., & Abrams, J. M. (2000) · Cell · doi:10.1016/s0092-8674(00)80627-3 · Cited by 473
Metadata
- Authors
- White, K., Tahaoglu, E., & Steller, H.
- Venue
- Science
- Published
- 1996-02-09
- Volume
- 271
- Issue
- 5250
- Pages
- 805-807
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2023153839
- Cited by
- 386
- References
- 17
- FWCI
- 11.75
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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