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Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins
Abstract
Heterotrimeric guanine nucleotide binding protein (G protein)-linked receptors of the chemoattractant subfamily can trigger adhesion through leukocyte integrins, and in this role they are thought to regulate immune cell-cell interactions and trafficking. In lymphoid cells transfected with formyl peptide or interleukin-8 receptors, agonist stimulation activated nucleotide exchange on the small guanosine triphosphate-binding protein RhoA in seconds. Inactivation of Rho by C3 transferase exoenzyme blocked agonist-induced lymphocyte α4β1 adhesion to vascular cell adhesion molecule-1 and neutrophil β2 integrin adhesion to fibrinogen. These findings suggest that Rho participates in signaling from chemoattractant receptors to trigger rapid adhesion in leukocytes.
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Citations
Cited by
Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
Self-citationBenard, V., Bohl, B. P., & Bokoch, G. M. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.19.13198 · Cited by 645
Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80019-9 · Cited by 556
Intracellular signalling controlling integrin activation in lymphocytes
Kinashi, T. (2005) · Nature Reviews Immunology · doi:10.1038/nri1646 · Cited by 477
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation
Ambruso, D. R., Knall, C., Abell, A. N., Panepinto, J., Kurkchubasche, A., Thurman, G., Gonzalez-Aller, C., Hiester, A., deBoer, M., Harbeck, R. J., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080074897 · Cited by 407
Metadata
- Authors
- Laudanna, C., Campbell, J. J., & Butcher, E. C.
- Venue
- Science
- Published
- 1996-02-16
- Volume
- 271
- Issue
- 5251
- Pages
- 981-983
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043290332
- Cited by
- 473
- References
- 0
- FWCI
- 24.12
- Type
- journal article
- Language
- en
- Open access
- closed
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- Laudanna, C., Campbell, J. J., & Butcher, E. C. (1996). Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins. Science. https://doi.org/10.1126/science.271.5251.981
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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