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Role of Rho in Chemoattractant-Activated Leukocyte Adhesion Through Integrins
Abstract
Heterotrimeric guanine nucleotide binding protein (G protein)-linked receptors of the chemoattractant subfamily can trigger adhesion through leukocyte integrins, and in this role they are thought to regulate immune cell-cell interactions and trafficking. In lymphoid cells transfected with formyl peptide or interleukin-8 receptors, agonist stimulation activated nucleotide exchange on the small guanosine triphosphate-binding protein RhoA in seconds. Inactivation of Rho by C3 transferase exoenzyme blocked agonist-induced lymphocyte α4β1 adhesion to vascular cell adhesion molecule-1 and neutrophil β2 integrin adhesion to fibrinogen. These findings suggest that Rho participates in signaling from chemoattractant receptors to trigger rapid adhesion in leukocytes.
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Cited by
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Roberts, A. W., Kim, C., Zhen, L., Lowe, J. B., Kapur, R., Petryniak, B., Spaetti, A., Pollock, J. D., Borneo, J. B., Bradford, G. B., et al. (1999) · Immunity · doi:10.1016/s1074-7613(00)80019-9 · Cited by 556
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Jansen, M., Yang, F.-C., Cancelas, J. A., Bailey, J. R., & Williams, D. A. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0216 · Cited by 50
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Metadata
- Authors
- Laudanna, C., Campbell, J. J., & Butcher, E. C.
- Venue
- Science
- Published
- 1996-02-16
- Volume
- 271
- Issue
- 5251
- Pages
- 981-983
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2043290332
- Cited by
- 473
- References
- 0
- FWCI
- 24.12
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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