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Blocked Ras Activation in Anergic CD4 + T Cells
Abstract
T cell anergy is a state of functional unresponsiveness characterized by the inability to produce interleukin-2 (IL-2) upon T cell receptor stimulation. The mitogen-activated protein kinases ERK-1 and ERK-2 and the guanosine triphosphate-binding protein p21 Ras were found to remain unactivated upon stimulation of anergic murine T helper cell 1 clones. The inability to activate the Ras pathway did not result from a defect in association among Shc, Grb-2, and murine Son of Sevenless, nor from a defect in their tyrosine phosphorylation. This block in Ras activation may lead to defective transactivation at activator protein 1 sites in anergic cells and may enable T cells to shut down IL-2 production selectively during anergy.
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Citations
Cited by
Schwartz, R. H. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141110 · Cited by 1,487
Mitogen-activated protein kinases in apoptosis regulation
Wada, T., & Penninger, J. M. (2004) · Oncogene · doi:10.1038/sj.onc.1207556 · Cited by 1,432
Patsoukis, N., Brown, J., Petkova, V., Liu, F., Li, L., & Boussiotis, V. A. (2012) · Science Signaling · doi:10.1126/scisignal.2002796 · Cited by 529
Immune resistance orchestrated by the tumor microenvironment
Gajewski, T. F., Meng, Y., Blank, C., Brown, I., Kacha, A., Kline, J., & Harlin, H. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00442.x · Cited by 437
Self-citationEssential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction
Jeon, M.-S., Atfield, A., Venuprasad, K., Krawczyk, C., Sarao, R., Elly, C., Yang, C., Arya, S., Bachmaier, K., Su, L., et al. (2004) · Immunity · doi:10.1016/j.immuni.2004.07.013 · Cited by 348
Metadata
- Authors
- Fields, P. E., Gajewski, T. F., & Fitch, F. W.
- Venue
- Science
- Published
- 1996-03
- Volume
- 271
- Issue
- 5253
- Pages
- 1276-1278
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2066331485
- Cited by
- 370
- References
- 0
- FWCI
- 16.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Fields, P. E., Gajewski, T. F., & Fitch, F. W. (1996). Blocked Ras Activation in Anergic CD4 + T Cells. Science. https://doi.org/10.1126/science.271.5253.1276
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