The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Bidirectional Control of Quantal Size by Synaptic Activity in the Hippocampus
Abstract
Analysis of strontium-induced asynchronous release of quanta from stimulated synapses revealed that long-term potentiation and long-term depression in the CA1 region of the mammalian hippocampus are associated with an increase and a decrease, respectively, in quantal size. At a single set of synapses, the increase in quantal size seen with long-term potentiation was completely reversed by depotentiating stimuli. Long-term potentiation and depression are also associated with an increase and decrease, respectively, in the frequency of quantal events, consistent with an all-or-none regulation (up or down) of clusters of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, a change in the release of transmitter, or both.
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“For instance, the size of “quantal” miniature EPSCs increases after LTP (364, 365).”
From Synaptic memory and CaMKII (2023) · cites this paper as [364]
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Cites
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Manabe, T., Renner, P., & Nicoll, R. A. (1992) · Nature · doi:10.1038/355050a0 · Cited by 366
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Research works printed but not linked: 32
- ASZTELY F, SYNAPTIC POTENTIATION IN THE HIPPOCAMPAL CA1 REGION INDUCED BY APPLICATION OF N-METHYL-D-ASPARTATE, BRAIN RESEARCH 558, 153 (1991). · DOI
- BAIN I. A., QUANTAL TRANSMITTER RELEASE MEDIATED BY STRONTIUM AT THE MOUSE MOTOR-NERVE TERMINAL, JOURNAL OF PHYSIOLOGY-LONDON 450, 63 (1992). · DOI
- BEKKERS M. J., QUANTAL ANALYSIS OF EPSCS RECORDED FROM SMALL NUMBERS OF SYNAPSES IN HIPPOCAMPAL CULTURES, JOURNAL OF NEUROPHYSIOLOGY 73, 1145 (1995). · DOI
- BLANTON G. M., WHOLE CELL RECORDING FROM NEURONS IN SLICES OF REPTILIAN AND MAMMALIAN CEREBRAL-CORTEX, JOURNAL OF NEUROSCIENCE METHODS 30, 203 (1989). · DOI
- BLISS TVP, A SYNAPTIC MODEL OF MEMORY - LONG-TERM POTENTIATION IN THE HIPPOCAMPUS, NATURE 361, 31 (1993). · DOI · Paper page
- 10.1126/science.7909958 · DOI
- 10.1126/science.7569903 · DOI
- DELCASTILLO J, QUANTAL COMPONENTS OF THE END-PLATE POTENTIAL, JOURNAL OF PHYSIOLOGY-LONDON 124, 560 (1954). · DOI
- DODGE A. F., STRONTIUM AND QUANTAL RELEASE OF TRANSMITTER AT NEUROMUSCULAR JUNCTION, JOURNAL OF PHYSIOLOGY-LONDON 200, 267 (1969). · DOI
- EDWARDS F, NEUROBIOLOGY - LTP IS A LONG-TERM PROBLEM, NATURE 350, 271 (1991). · DOI · Paper page
- GODA Y, 2 COMPONENTS OF TRANSMITTER RELEASE AT A CENTRAL SYNAPSE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 12942 (1994). · DOI
- GROVER M. L., DIFFERENT MECHANISMS MAY BE REQUIRED FOR MAINTENANCE OF NIMDA RECEPTOR-DEPENDENT AND INDEPENDENT FORMS OF LONG-TERM POTENTIATION, SYNAPSE 19, 121 (1995). · DOI
- HANSE E, TEA ELICITS 2 DISTINCT POTENTIATIONS OF SYNAPTIC TRANSMISSION IN THE CA1 REGION OF THE HIPPOCAMPAL SLICE, JOURNAL OF NEUROSCIENCE 14, 5028 (1994). · DOI · Paper page
- HUBER M. K., DISTINCT LTP INDUCTION MECHANISMS - CONTRIBUTION OF NMDA RECEPTORS AND VOLTAGE-DEPENDENT CALCIUM CHANNELS, JOURNAL OF NEUROPHYSIOLOGY 73, 270 (1995). · DOI
- ISAAC JTR, EVIDENCE FOR SILENT SYNAPSES - IMPLICATIONS FOR THE EXPRESSION OF LTP, NEURON 15, 427 (1995). · DOI · Paper page
- KATZ B, NERVE MUSCLE SYNAPSE (1966).
- KULLMANN M. D., LONG-TERM POTENTIATION IS ASSOCIATED WITH INCREASES IN QUANTAL CONTENT AND QUANTAL AMPLITUDE, NATURE 357, 240 (1992). · DOI
- KULLMANN M. D., CA2+ ENTRY VIA POSTSYNAPTIC VOLTAGE-SENSITIVE CA2+ CHANNELS CAN TRANSIENTLY POTENTIATE EXCITATORY SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS, NEURON 9, 1175 (1992). · DOI · Paper page
- LARKMAN A, PRESYNAPTIC RELEASE PROBABILITY INFLUENCES THE LOCUS OF LONG-TERM POTENTIATION, NATURE 360, 70 (1992). · DOI
- LARKMAN U. A., SYNAPTIC PLASTICITY - HIPPOCAMPAL LTP, CURRENT OPINION IN NEUROBIOLOGY 5, 324 (1995). · DOI
- LIAO D, DIRECT MEASUREMENT OF QUANTAL CHANGES UNDERLYING LONG-TERM POTENTIATION IN CA1 HIPPOCAMPUS, NEURON 9, 1089 (1992). · DOI
- MALGAROLI A, GLUTAMATE-INDUCED LONG-TERM POTENTIATION OF THE FREQUENCY OF MINIATURE SYNAPTIC CURRENTS IN CULTURED HIPPOCAMPAL-NEURONS, NATURE 357, 134 (1992). · DOI
- MALINOW R, PRESYNAPTIC ENHANCEMENT SHOWN BY WHOLE-CELL RECORDINGS OF LONG-TERM POTENTIATION IN HIPPOCAMPAL SLICES, NATURE 346, 177 (1990). · DOI
- 10.1126/science.7916483 · DOI · Paper page
- MEIRI U, ACTIVATION OF TRANSMITTER RELEASE BY STRONTIUM AND CALCIUM IONS AT NEUROMUSCULAR JUNCTION, JOURNAL OF PHYSIOLOGY-LONDON 215, 709 (1971). · DOI
- MILEDI R, STONTIUM AS A SUBSTITUTE FOR CALCIUM IN PROCESS OF TRANSMITTER RELEASE AT NEUROMUSCULAR JUNCTION, NATURE 212, 1233 (1966). · DOI
- MULKEY M. R., MECHANISMS UNDERLYING INDUCTION OF HOMOSYNAPTIC LONG-TERM DEPRESSION IN AREA CA1 OF THE HIPPOCAMPUS, NEURON 9, 967 (1992). · DOI · Paper page
- NICOLL A. R., CONTRASTING PROPERTIES OF 2 FORMS OF LONG-TERM POTENTIATION IN THE HIPPOCAMPUS, NATURE 377, 115 (1995). · DOI
- REDMAN S, QUANTAL ANALYSIS OF SYNAPTIC POTENTIALS IN NEURONS OF THE CENTRAL NERVOUS-SYSTEM, PHYSIOLOGICAL REVIEWS 70, 165 (1990). · DOI
- STEVENS F. C., CHANGES IN RELIABILITY OF SYNAPTIC FUNCTION AS A MECHANISM FOR PLASTICITY, NATURE 371, 704 (1994). · DOI
- WYLLIE DJA, A ROLE FOR PROTEIN-KINASES AND PHOSPHATASES IN THE CA2+-INDUCED ENHANCEMENT OF HIPPOCAMPAL AMPA RECEPTOR-MEDIATED SYNAPTIC RESPONSES, NEURON 13, 635 (1994). · DOI · Paper page
- ZENGEL E. J., DIFFERENTIAL-EFFECTS OF BA2+, SR2+, AND CA2+ ON STIMULATION-INDUCED CHANGES IN TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR-JUNCTION, JOURNAL OF GENERAL PHYSIOLOGY 76, 175 (1980). · DOI
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Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729
Self-citationElectrical and synaptic integration of glioma into neural circuits
Venkatesh, H. S., Morishita, W., Geraghty, A. C., Silverbush, D., Gillespie, S. M., Arzt, M., Tam, L. T., Espenel, C., Ponnuswami, A., Ni, L., et al. (2019) · Nature · doi:10.1038/s41586-019-1563-y · Cited by 1,366
“To test this hypothesis further, we replaced extracellular calcium with strontium, a manipulation that facilitates asynchronous presynaptic vesicle release 14 (Fig.”
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Metadata
- Authors
- Oliet, S. H. R., Malenka, R. C., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Science
- Published
- 1996-03
- Volume
- 271
- Issue
- 5253
- Pages
- 1294-1297
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2057637786
- Cited by
- 209
- References
- 0
- Citations by year
- 2025: 7 · 2024: 3 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 7 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 6 · 2012: 6
- FWCI
- 7.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- quantal size, synaptic transmission, long-term potentiation, long-term depression, hippocampal CA1, depotentiation, synaptic plasticity
- MeSH terms
- Animals, Calcium, Electric Stimulation, Evoked Potentials, Guinea Pigs, Hippocampus, Synaptic Transmission, Neuronal Plasticity, Neurons, Strontium, Synapses, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Patch-Clamp Techniques, Rats, In Vitro Techniques
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