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Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus
Abstract
The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.
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Metadata
- Authors
- Sarzotti, M., Robbins, D. S., & Hoffman, P. M.
- Venue
- Science
- Published
- 1996-03-22
- Volume
- 271
- Issue
- 5256
- Pages
- 1726-1728
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084147684
- Cited by
- 446
- References
- 0
- FWCI
- 14.99
- Type
- journal article
- Language
- en
- Open access
- closed
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- Sarzotti, M., Robbins, D. S., & Hoffman, P. M. (1996). Induction of Protective CTL Responses in Newborn Mice by a Murine Retrovirus. Science. https://doi.org/10.1126/science.271.5256.1726
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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