The DOI matches its Crossref record; 110 of the 110 references it cites were found in a registry or an index.
Neonatal and early life vaccinology
Open accessAbstract
Preclinical and human vaccine studies indicate that, although neonatal immunisation does not generally lead to rapid and strong antibody responses, it may result in an efficient immunological priming, which can serve as an excellent basis for future responses. The apparent impairment of CD4 and CD8 T-cell function in early life seems to result from suboptimal antigen-presenting cells-T cell interactions, which can be overcome by use of specific adjuvants or delivery systems. Although persistence of maternal antibodies may limit infant antibody responses, induction of T-cell responses largely remain unaffected by these passively transferred antibodies. Thus, neonatal priming and early boosting with vaccine formulations optimised for sufficient early life immunogenicity and maximal safety profiles, could allow better control of the huge infectious disease burden in early life.
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Induction of T H 1 and T H 2 Immunity in Neonatal Mice
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Belkaid, Y., & Hand, T. W. (2014) · Cell · doi:10.1016/j.cell.2014.03.011 · Cited by 5,385
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Zimmermann, P., & Curtis, N. (2019) · Clinical Microbiology Reviews · doi:10.1128/cmr.00084-18 · Cited by 939
B-cell responses to vaccination at the extremes of age
Siegrist, C.-A., & Aspinall, R. (2009) · Nature Reviews Immunology · doi:10.1038/nri2508 · Cited by 659
Self-citationThe microbiome in autoimmune diseases
De Luca, F., & Shoenfeld, Y. (2018) · Clinical and Experimental Immunology · doi:10.1111/cei.13158 · Cited by 510
Addressing parents’ concerns: do multiple vaccines overwhelm or weaken the infant's immune system?
Offit, P. A., Quarles, J., Gerber, M. A., Hackett, C. J., Marcuse, E. K., Kollman, T. R., Gellin, B. G., & Landry, S. (2002) · Pediatrics · doi:10.1542/peds.109.1.124 · Cited by 312
Metadata
- Authors
- Siegrist, C.-A.
- Venue
- Vaccine
- Publisher
- Elsevier BV
- Published
- 2001-05
- Volume
- 19
- Issue
- 25-26
- Pages
- 3331-3346
- ISSN
- 0264-410X (ISSN-L)
- OpenAlex
- W2161291046
- Cited by
- 593
- References
- 110
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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