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Induction of T H 1 and T H 2 Immunity in Neonatal Mice
Abstract
The neonatal period has been thought of as a window in ontogeny, during which the developing immune system is particularly susceptible to tolerization. In the present study, the classic system for induction of neonatal tolerance to protein antigens was reexamined in mice. The presumably tolerogenic protocol was found to trigger a vigorous T helper cell type 2 (T H 2) immune response. Thus, neonatal “tolerization” induces immune deviation, not tolerance in the immunological sense. Neonates are not immune privileged but generate T H 2 or T H 1 responses, depending on the mode of immunization.
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Cited by
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Prescott, S. L., Macaubas, C., Holt, B. J., Smallacombe, T. B., Loh, R., Sly, P. D., & Holt, P. G. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.160.10.4730 · Cited by 788
Neonatal Tolerance Revisited: Turning on Newborn T Cells with Dendritic Cells
Ridge, J. P., Fuchs, E. J., & Matzinger, P. (1996) · Science · doi:10.1126/science.271.5256.1723 · Cited by 760
The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4
Ho, I.-C., Hodge, M. R., Rooney, J. W., & Glimcher, L. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81299-4 · Cited by 667
DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
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Metadata
- Authors
- Forsthuber, T., Yip, H. C., & Lehmann, P. V.
- Venue
- Science
- Published
- 1996-03-22
- Volume
- 271
- Issue
- 5256
- Pages
- 1728-1730
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2027729283
- Cited by
- 681
- References
- 0
- FWCI
- 25.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Forsthuber, T., Yip, H. C., & Lehmann, P. V. (1996). Induction of T H 1 and T H 2 Immunity in Neonatal Mice. Science. https://doi.org/10.1126/science.271.5256.1728
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
