The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
Abstract
▪ Abstract The secondary lymphoid tissues are located at strategic sites where foreign antigens can be efficiently brought together with immune system regulatory and effector cells. The organized structure of the secondary lymphoid tissues is thought to enhance the sensitivity of antigen recognition and to support proper regulation of the activation and maturation of the antigen-responsive lymphoid cells. Although a substantial amount is known about the cellular elements that compose the lymphoid and nonlymphoid components of the secondary lymphoid tissues, information concerning the signals that control the development of the tissues and that maintain the organized tissue microenvironment remain undefined. Studies over the past few years have identified lymphotoxin as a critical signaling molecule not only for the organogenesis of secondary lymphoid tissues but for the maintenance of aspects of their microarchitecture as well. Additional signaling molecules that contribute to the formation of normal lymphoid tissue structure are being identified at an accelerating pace. Analyses of mouse strains with congenital defects in different aspects of secondary lymphoid tissue development are beginning to clarify the role of these tissues in immune responses and host defense. This review focuses on studies defining recently identified crucial signals for the biogenesis of secondary lymphoid organs and for the maintenance of their proper microarchitecture. It also discusses new insights into how the structure of these tissues supports effective immune responses.
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Chaplin, D. D. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.980 · Cited by 2,235
Self-citationBarthel, M., Hapfelmeier, S., Quintanilla-Martínez, L., Kremer, M., Rohde, M., Hogardt, M., Pfeffer, K., Rüssmann, H., & Hardt, W.-D. (2003) · Infection and Immunity · doi:10.1128/iai.71.5.2839-2858.2003 · Cited by 1,020
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Metadata
- Authors
- Fu, Y.-X., & Chaplin, D. D.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 1999-04
- Volume
- 17
- Issue
- 1
- Pages
- 399-433
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2101580628
- Cited by
- 616
- References
- 98
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES. https://app.cochat.ai/papers/10.1146/annurev.immunol.17.1.399
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- Fu, Y.-X., & Chaplin, D. D. (1999). DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.17.1.399
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
