The DOI matches its Crossref record.
Light-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock
Abstract
Two genes, period ( per ) and timeless ( tim ), are required for production of circadian rhythms in Drosophila . The proteins encoded by these genes (PER and TIM) physically interact, and the timing of their association and nuclear localization is believed to promote cycles of per and tim transcription through an autoregulatory feedback loop. Here it is shown that TIM protein may also couple this molecular pacemaker to the environment, because TIM is rapidly degraded after exposure to light. TIM accumulated rhythmically in nuclei of eyes and in pacemaker cells of the brain. The phase of these rhythms was differentially advanced or delayed by light pulses delivered at different times of day, corresponding with phase shifts induced in the behavioral rhythms.
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Citations
Cited by
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900
A Serum Shock Induces Circadian Gene Expression in Mammalian Tissue Culture Cells
Balsalobre, A., Damiola, F., & Schibler, U. (1998) · Cell · doi:10.1016/s0092-8674(00)81199-x · Cited by 2,001
Molecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
Self-citationTian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81637-2 · Cited by 912
Metadata
- Authors
- Myers, M. P., Wager-Smith, K., Rothenfluh-Hilfiker, A., & Young, M. W.
- Venue
- Science
- Published
- 1996-03-22
- Volume
- 271
- Issue
- 5256
- Pages
- 1736-1740
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2005174604
- Cited by
- 465
- References
- 0
- FWCI
- 12.91
- Type
- journal article
- Language
- en
- Open access
- closed
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- Myers, M. P., Wager-Smith, K., Rothenfluh-Hilfiker, A., & Young, M. W. (1996). Light-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock. Science. https://doi.org/10.1126/science.271.5256.1736
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