Cited by 912Circadian rhythm and melatoninLight effects on plantsNeurobiology and Insect Physiology Research

CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity

Open access
Emery, Patrick, So, W.Venus, Kaneko, Maki, Hall, Jeffrey C, Rosbash, Michael·1998·Cell

Abstract

Light is a major environmental signal for circadian rhythms. We have identified and analyzed cry, a novel Drosophila cryptochrome gene. All characterized family members are directly photosensitive and include plant blue light photoreceptors. We show that cry transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock, and cycle. We also show that cry protein levels are dramatically affected by light exposure. Importantly, circadian photosensitivity is increased in a cry-overexpressing strain. These physiological and genetic data therefore link a specific photoreceptor molecule to circadian rhythmicity. Taken together with the data in the accompanying paper, we propose that CRY is a major Drosophila photoreceptor dedicated to the resetting of circadian rhythms.

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Crossref · 10.1016/s0092-8674(00)81637-2

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85 of 85 references verified0 citation errors · 0 not checkable

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  • Members of the d-Cry/Cry1/Lcry family can function as photoreceptors activated by short-wavelength light in insect and annelid circadian clocks.

    “members of the d-Cry/Cry1/Lcry family can function as photoreceptors (activated by short-wavelength light) in insect and annelid circadian clocks (22, 33, 35, 36)”

    From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [35]

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Authors
Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M.
Affiliations
  • Brandeis University (US)
  • Howard Hughes Medical Institute (US)
Corresponding author
Rosbash, Michael
Venue
Cell
Publisher
Elsevier BV
Published
1998-11
Volume
95
Issue
5
Pages
669-679
ISSN
0092-8674 (ISSN-L)
OpenAlex
W2136757266
Cited by
912
References
85
Citations by year
2026: 23 · 2025: 37 · 2024: 28 · 2023: 39 · 2022: 32 · 2021: 36 · 2020: 33 · 2019: 49 · 2018: 50 · 2017: 35 · 2016: 26 · 2015: 22 · 2014: 39 · 2013: 28 · 2012: 18
FWCI
15.36
Type
journal article
Language
en
Open access
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
Keywords
cryptochrome, crying, Drosophila, circadian rhythm, light entrainment, photoreceptors, clock genes, period, TIMELESS, clocks, cycles, transcriptional regulation
MeSH terms
Animals, Circadian Rhythm, Drosophila, Eye Proteins, Female, Flavoproteins, Light, Male, Molecular Sequence Data, Nuclear Proteins, Transcription, Genetic, Trans-Activators, Photoreceptor Cells, Invertebrate, Insect Proteins, Drosophila Proteins, Animals, Genetically Modified, Receptors, G-Protein-Coupled, Basic Helix-Loop-Helix Proteins, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins

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