CRY, a Drosophila clock and light-regulated cryptochrome, is a major contributor to circadian rhythm resetting and photosensitivity
Open accessAbstract
Light is a major environmental signal for circadian rhythms. We have identified and analyzed cry, a novel Drosophila cryptochrome gene. All characterized family members are directly photosensitive and include plant blue light photoreceptors. We show that cry transcription is under circadian regulation, influenced by the Drosophila clock genes period, timeless, Clock, and cycle. We also show that cry protein levels are dramatically affected by light exposure. Importantly, circadian photosensitivity is increased in a cry-overexpressing strain. These physiological and genetic data therefore link a specific photoreceptor molecule to circadian rhythmicity. Taken together with the data in the accompanying paper, we propose that CRY is a major Drosophila photoreceptor dedicated to the resetting of circadian rhythms.
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Members of the d-Cry/Cry1/Lcry family can function as photoreceptors activated by short-wavelength light in insect and annelid circadian clocks.
“members of the d-Cry/Cry1/Lcry family can function as photoreceptors (activated by short-wavelength light) in insect and annelid circadian clocks (22, 33, 35, 36)”
From An Overview of Monthly Rhythms and Clocks (2017) · cites this paper as [35]
Cites
Clock Mutants of Drosophila melanogaster
Konopka, R. J., & Benzer, S. (1971) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.68.9.2112 · Cited by 2,287 · see citing works
HY4 gene of A. thaliana encodes a protein with characteristics of a blue-light photoreceptor
Ahmad, M., & Cashmore, A. R. (1993) · Nature · doi:10.1038/366162a0 · Cited by 1,270 · see citing works
Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels
Hardin, P. E., Hall, J. C., & Rosbash, M. (1990) · Nature · doi:10.1038/343536a0 · Cited by 1,156 · see citing works
Self-citationThe cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81638-4 · Cited by 968 · see citing works
Self-citationShigeyoshi, Y., Taguchi, K., Yamamoto, S., Takekida, S., Yan, L., Tei, H., Moriya, T., Shibata, S., Loros, J. J., Dunlap, J. C., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80494-8 · Cited by 891 · see citing works
A Differential Response of Two Putative Mammalian Circadian Regulators, mper1and mper2, to Light
Albrecht, U., Sun, Z. S., Eichele, G., & Lee, C. C. (1997) · Cell · doi:10.1016/s0092-8674(00)80495-x · Cited by 879 · see citing works
Zylka, M. J., Shearman, L. P., Weaver, D. R., & Reppert, S. M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80492-4 · Cited by 865 · see citing works
double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation
Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works
Closing the Circadian Loop: CLOCK-Induced Transcription of Its Own Inhibitors per and tim
Darlington, T. K., Wager‐Smith, K., Ceriani, M. F., Staknis, D., Gekakis, N., Steeves, T. D. L., Weitz, C. J., Takahashi, J. S., & Kay, S. A. (1998) · Science · doi:10.1126/science.280.5369.1599 · Cited by 826 · see citing works
Circadian oscillation of a mammalian homologue of the Drosophila period gene
Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., & Sakaki, Y. (1997) · Nature · doi:10.1038/39086 · Cited by 792 · see citing works
Regulation of Flowering Time byArabidopsisPhotoreceptors
Guo, H., Yang, H., Mockler, T. C., & Lin, C. (1998) · Science · doi:10.1126/science.279.5355.1360 · Cited by 786 · see citing works
Two period Homologs: Circadian Expression and Photic Regulation in the Suprachiasmatic Nuclei
Shearman, L. P., Zylka, M. J., Weaver, D. R., Kolakowski, L. F., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80417-1 · Cited by 781 · see citing works
Expression of a Gene Cluster kaiABC as a Circadian Feedback Process in Cyanobacteria
Ishiura, M., Kutsuna, S., Aoki, S., Iwasaki, H., Andersson, C. R., Tanabe, A., Golden, S. S., Johnson, C. H., & Kondo, T. (1998) · Science · doi:10.1126/science.281.5382.1519 · Cited by 760 · see citing works
Allada, R., White, N. E., So, W. V., Hall, J. C., & Rosbash, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81440-3 · Cited by 744 · see citing works
Self-citationRIGUI, a putative mammalian ortholog of the Drosophila period gene.
Sun, Z. S., Albrecht, U., Zhuchenko, O., Bailey, J., Eichele, G., & Lee, C.-C. (1997) · Cell · doi:10.1016/s0092-8674(00)80366-9 · Cited by 706 · see citing works
Arabidopsis NPH1: A Protein Kinase with a Putative Redox-Sensing Domain
Huala, E., Oeller, P. W., Emmanuel Liscum, A., Han, I., Larsen, E., & Briggs, W. R. (1997) · Science · doi:10.1126/science.278.5346.2120 · Cited by 706 · see citing works
The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε
Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works
Loss of Circadian Behavioral Rhythms and per RNA Oscillations in the Drosophila Mutant timeless
Sehgal, A., Price, J. L., Man, B., & Young, M. W. (1994) · Science · doi:10.1126/science.8128246 · Cited by 651 · see citing works
Rutila, J. E., Suri, V., Le, M., So, W. V., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81441-5 · Cited by 643 · see citing works
Self-citationIndependent Photoreceptive Circadian Clocks Throughout Drosophila
Plautz, J. D., Kaneko, M. A. N., Hall, J. C., & Kay, S. A. (1997) · Science · doi:10.1126/science.278.5343.1632 · Cited by 640 · see citing works
Self-citationNegative Feedback Defining a Circadian Clock: Autoregulation of the Clock Gene frequency
Aronson, B. D., Johnson, K. A., Loros, J., & Dunlap, J. (1994) · Science · doi:10.1126/science.8128244 · Cited by 605 · see citing works
Crystal Structure of DNA Photolyase from Escherichia coli
Park, H.-W., Kim, S., Sancar, A., & Deisenhofer, J. (1995) · Science · doi:10.1126/science.7604260 · Cited by 585 · see citing works
Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus.
Kornhauser, J., Nelson, D., Mayo, K., & Takahashi, J. (1990) · Neuron · doi:10.1016/0896-6273(90)90303-w · Cited by 530 · see citing works
Lin, C., Yang, H., Guo, H., Mockler, T. C., Chen, J., & Cashmore, A. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2686 · Cited by 519 · see citing works
Restoration of circadian behavioural rhythms by gene transfer in Drosophila
Bargiello, T. A., Jackson, F. R., & Young, M. W. (1984) · Nature · doi:10.1038/312752a0 · Cited by 498 · see citing works
A light-entrainment mechanism for the Drosophila circadian clock
Zeng, H., Qian, Z., Myers, M. P., & Rosbash, M. (1996) · Nature · doi:10.1038/380129a0 · Cited by 479 · see citing works
Self-citationLight-Induced Degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock
Myers, M. P., Wager‐Smith, K., Rothenfluh, A., & Young, M. W. (1996) · Science · doi:10.1126/science.271.5256.1736 · Cited by 465 · see citing works
Reddy, P., Zehring, W. A., Wheeler, D. A., Pirrotta, V., Hadfield, C., Hall, J. C., & Rosbash, M. (1984) · Cell · doi:10.1016/0092-8674(84)90265-4 · Cited by 423 · see citing works
Self-citationTemporal phosphorylation of the Drosophila period protein.
Edery, I., Zwiebel, L. J., Dembinska, M. E., & Rosbash, M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2260 · Cited by 410 · see citing works
Self-citationMiyamoto, Y., & Sancar, A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.11.6097 · Cited by 406 · see citing works
Zerr, D., Hall, J. C., Rosbash, M., & Siwicki, K. K. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-08-02749.1990 · Cited by 401 · see citing works
Self-citationHunter-Ensor, M., Ousley, A. H., & Sehgal, A. (1996) · Cell · doi:10.1016/s0092-8674(00)81046-6 · Cited by 395 · see citing works
Block in Nuclear Localization of period Protein by a Second Clock Mutation, timeless
Vosshall, L. B., Price, J. L., Sehgal, A., Sáez, L., & Young, M. W. (1994) · Science · doi:10.1126/science.8128247 · Cited by 371 · see citing works
Gekakis, N., Sáez, L., Delahaye-Brown, A.-M., Myers, M. P., Sehgal, A., Young, M. W., & Weitz, C. J. (1995) · Science · doi:10.1126/science.270.5237.811 · Cited by 371 · see citing works
Sehgal, A., Rothenfluh, A., Hunter-Ensor, M., Chen, Y.-F., Myers, M. P., & Young, M. W. (1995) · Science · doi:10.1126/science.270.5237.808 · Cited by 370 · see citing works
Light-induced resetting of a circadian clock is mediated by a rapid increase in frequency transcript
Crosthwaite, S. K., Loros, J., & Dunlap, J. (1995) · Cell · doi:10.1016/s0092-8674(05)80005-4 · Cited by 358 · see citing works
Control of cell lineage-specific development and transcription by bHLH-PAS proteinsPreprint
Crews, S. T. (1998) · Genes & Development · doi:10.1101/gad.12.5.607 · Cited by 346 · see citing works
Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and Timeless
Sáez, L., & Young, M. W. (1996) · Neuron · doi:10.1016/s0896-6273(00)80222-6 · Cited by 330 · see citing works
Behavior in Light-Dark Cycles of Drosophila Mutants That Are Arrhythmic, Blind, or Both
Wheeler, D. A., Hamblen, M. J., Dushay, M. S., & Hall, J. C. (1993) · Journal of Biological Rhythms · doi:10.1177/074873049300800106 · Cited by 302 · see citing works
Self-citationPutative Human Blue-Light Photoreceptors hCRY1 and hCRY2 Are Flavoproteins
Hsu, D. S., Zhao, X., Zhao, S., Kazantsev, A., Wang, R.-P., Todo, T., Wei, Y.-F., & Sancar, A. (1996) · Biochemistry · doi:10.1021/bi962209o · Cited by 291 · see citing works
Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei.
D, N. A. M., Sagar, S. M., Sharp, F. R., & Schwartz, W. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.15.5959 · Cited by 290 · see citing works
Curtin, K. D., Huang, Z. J., & Rosbash, M. (1995) · Neuron · doi:10.1016/0896-6273(95)90292-9 · Cited by 277 · see citing works
Self-citationResetting the Drosophila Clock by Photic Regulation of PER and a PER-TIM Complex
Lee, C., Parikh, V., Itsukaichi, T., Bae, K., & Edery, I. (1996) · Science · doi:10.1126/science.271.5256.1740 · Cited by 274 · see citing works
Positional Cloning and Sequence Analysis of the Drosophila Clock Gene, timeless
Myers, M. P., Wager‐Smith, K., Wesley, C. S., Young, M. W., & Sehgal, A. (1995) · Science · doi:10.1126/science.270.5237.805 · Cited by 270 · see citing works
Post‐transcriptional regulation contributes to Drosophila clock gene mRNA cycling
So, W. V., & Rosbash, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.23.7146 · Cited by 258 · see citing works
Self-citationKaneko, M. A. N., Helfrich‐Förster, C., & Hall, J. C. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-17-06745.1997 · Cited by 256 · see citing works
Self-citationTodo, T., Ryo, H., Yamamoto, K., Toh, H., Inui, T., Ayaki, H., Nomura, T., & Ikenaga, M. (1996) · Science · doi:10.1126/science.272.5258.109 · Cited by 247 · see citing works
A Circadian Enhancer Mediates PER-Dependent mRNA Cycling in Drosophila melanogaster
Hao, H., Allen, D. L., & Hardin, P. E. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.7.3687 · Cited by 239 · see citing works
A light‐independent oscillatory gene mPer3 in mouse SCN and OVLT
Takumi, T., Taguchi, K., Miyake, S., Sakakida, Y., Takashima, N., Matsubara, C., Maebayashi, Y., Okumura, K., Takekida, S., Yamamoto, S., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.16.4753 · Cited by 236 · see citing works
Lee, C., Bae, K., & Edery, I. (1998) · Neuron · doi:10.1016/s0896-6273(00)80601-7 · Cited by 231 · see citing works
A neuronal ryanodine receptor mediates light-induced phase delays of the circadian clock
Ding, J., Buchanan, G. F., Tischkau, S. A., Chen, D., Kuriashkina, L. R., Faiman, L. E., Alster, J. M., McPherson, P. S., Campbell, K. P., & Gillette, M. U. (1998) · Nature · doi:10.1038/28639 · Cited by 227 · see citing works
Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.
Zeng, H., Hardin, P. E., & Rosbash, M. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06666.x · Cited by 222 · see citing works
Self-citationA new class of DNA photolyases present in various organisms including aplacental mammals.
Yasui, A., Eker, A. P., Yasuhira, S., Yajima, H., Kobayashi, T., Takao, M., & Oikawa, A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06961.x · Cited by 219 · see citing works
Circadian oscillations in period gene mRNA levels are transcriptionally regulated.
Hardin, P. E., Hall, J. C., & Rosbash, M. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.24.11711 · Cited by 218 · see citing works
Self-citationRegulation of jun -B Messenger RNA and AP-1 Activity by Light and a Circadian Clock
Kornhauser, J. M., Nelson, D. E., Mayo, K. E., & Takahashi, J. S. (1992) · Science · doi:10.1126/science.1549784 · Cited by 218 · see citing works
Cryptochrome blue-light photoreceptors of Arabidopsis implicated in phototropism
Ahmad, M., Jarillo, J. A., Smirnova, O., & Cashmore, A. R. (1998) · Nature · doi:10.1038/33701 · Cited by 171 · see citing works
Hamblen, M. J., Zehring, W. A., Kyriacou, C. P., et al. (1986) · Journal of Neurogenetics · doi:10.3109/01677068609106855 · Cited by 170 · see citing works
Ahmad, M., Jarillo, J. A., & Cashmore, A. R. (1998) · The Plant Cell · doi:10.1105/tpc.10.2.197 · Cited by 165 · see citing works
Molecular Evolution of the Photolyase–Blue-Light Photoreceptor Family
Kanai, S., Kikuno, R., Toh, H., Ryo, H., & Todo, T. (1997) · Journal of Molecular Evolution · doi:10.1007/pl00006258 · Cited by 158 · see citing works
Shedding Light on the Biological Clock
Foster, F. (1998) · Neuron · doi:10.1016/s0896-6273(00)80464-x · Cited by 148 · see citing works
Suri, V., Qian, Z., Hall, J. C., & Rosbash, M. (1998) · Neuron · doi:10.1016/s0896-6273(00)80529-2 · Cited by 148 · see citing works
Self-citationPhase Shifting of the Circadian Clock by Induction of the Drosophila period Protein
Edery, I., Rutila, J. E., & Rosbash, M. (1994) · Science · doi:10.1126/science.8284676 · Cited by 146 · see citing works
Self-citationDushay, M. S., Rosbash, M., & Hall, J. C. (1989) · Journal of Biological Rhythms · doi:10.1177/074873048900400101 · Cited by 143 · see citing works
Self-citationSoni, B. G., Philp, A. R., Foster, F., & Knox, B. E. (1998) · Nature · doi:10.1038/27794 · Cited by 138 · see citing works
Circadian clock in Malpighian tubules
Giebultowicz, J. M., & Hege, D. M. (1997) · Nature · doi:10.1038/386664a0 · Cited by 136 · see citing works
Rhythms of Drosophila period gene expression in culture
Emery, I. F., Noveral, J., Jamison, C. F., & Siwicki, K. K. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4092 · Cited by 133 · see citing works
Hardin, P. E. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.11.7211 · Cited by 125 · see citing works
Altered circadian pacemaker functions and cyclic AMP rhythms in the drosophila learning mutant dunce
Levine, J. D., Casey, C. I., Kalderon, D., et al. (1994) · Neuron · doi:10.1016/0896-6273(94)90262-3 · Cited by 124 · see citing works
Marrus, S. B., Zeng, H., & Rosbash, M. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01080.x · Cited by 123 · see citing works
Self-citationYang, Z., Emerson, M. M., Su, H. S., & Sehgal, A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80528-0 · Cited by 123 · see citing works
No "End of History" for Photolyases
Sancar, A. (1996) · Science · doi:10.1126/science.272.5258.48 · Cited by 122 · see citing works
Action Spectra for Phase Shifts of a Circadian Rhythm in Drosophila
Frank, K. D., & Zimmerman, W. F. (1969) · Science · doi:10.1126/science.163.3868.688 · Cited by 117 · see citing works
Photosensitivity of the Circadian Rhythm and of Visual Receptors in Carotenoid-DepletedDrosophila
Zimmerman, W. F., & Goldsmith, T. H. (1971) · Science · doi:10.1126/science.171.3976.1167 · Cited by 115 · see citing works
Rutila, J. E., Zeng, H., Le, M., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80223-8 · Cited by 102 · see citing works
Schwartz, W. J., Takeuchi, J., Shannon, W. D., Davis, E. M., & Anonin, N. (1994) · Neuroscience · doi:10.1016/0306-4522(94)90082-5 · Cited by 94 · see citing works
Circadian rhythms: molecular basis of the clock
Wilsbacher, L. D., & Takahashi, J. S. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80017-8 · Cited by 80 · see citing works
Saunders, D. S., Gillanders, S. W., & Lewis, R. D. (1994) · Journal of Insect Physiology · doi:10.1016/0022-1910(94)90134-1 · Cited by 79 · see citing works
Zhao, S., & Sancar, A. (1997) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1997.tb03214.x · Cited by 78 · see citing works
Paietta, J. V., & Sargent, M. (1981) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.78.9.5573 · Cited by 72 · see citing works
A new gene encoding a putative transcription factor regulated by the Drosophila circadian clock
Rouyer, F., Rachidi, M., Pikielny, C. W., et al. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3944 · Cited by 63 · see citing works
DETAILED ACTION SPECTRUM FOR THE DELAY SHIFT IN PUPAE EMERGENCE OF DROSOPHILA PSEUDOOBSCURA*
Klemm, E., & Ninnemann, H. (1976) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1976.tb06838.x · Cited by 60 · see citing works
Gelder, R. N. V., & Krasnow, M. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00507.x · Cited by 56 · see citing works
The tim SL Mutant Affects a Restricted Portion of the Drosophila melanogaster Circadian Cycle
Rutila, J. E., Maltseva, O. N., & Rosbash, M. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000200 · Cited by 44 · see citing works
Self-citationCircadian Behavior and Plasticity of Light-Induced c- fos Expression in SCN of tau Mutant Hamsters
Shimomura, K., Kornhauser, J. M., Wisor, J. P., Umezu, T., Yamazaki, S., Ihara, N. L., Takahashi, J. S., & Menaker, M. (1998) · Journal of Biological Rhythms · doi:10.1177/074873098129000147 · Cited by 26 · see citing works
The role of conserved amino acids in substrate binding and discrimination by photolyase
Baer, M., & Sancar, G. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)85476-5 · Cited by 25 · see citing works
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Sorted by citations
Molecular Bases for Circadian Clocks
Dunlap, J. C. (1999) · Cell · doi:10.1016/s0092-8674(00)80566-8 · Cited by 2,900 · see citing works
Resetting of circadian time in peripheral tissues by glucocorticoid signaling
Balsalobre, A., Brown, S. A., Marcacci, L., Tronche, F., Kellendonk, C., Reichardt, H. M., Schütz, G., & Schibler, U. (2000) · Science · doi:10.1126/science.289.5488.2344 · Cited by 1,859 · see citing works
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621 · see citing works
PAS Domains: Internal Sensors of Oxygen, Redox Potential, and Light
Taylor, B. L., & Zhulin, I. B. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.2.479-506.1999 · Cited by 1,632 · see citing works
mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617 · see citing works
Mammalian Cry1 and Cry2 are essential for maintenance of circadian rhythms
Horst, G. T. J. V. D., Muijtjens, M., Kobayashi, K., Takano, R., Kanno, S.-I., Takao, M., Wit, J. D., Verkerk, A., Eker, A. P. M., Leenen, D. V., et al. (1999) · Nature · doi:10.1038/19323 · Cited by 1,402 · see citing works
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245 · see citing works
The cryb mutation identifies cryptochrome as a circadian photoreceptor in Drosophila
Stanewsky, R., Kaneko, M., Emery, P., Beretta, B., Wager-Smith, K., Kay, S. A., Rosbash, M., & Hall, J. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81638-4 · Cited by 968 · see citing works
Self-citationThe cryptochromes: blue light photoreceptors in plants and animals
Chaves, I., Pokorny, R., Byrdin, M., Hoang, N., Ritz, T., Brettel, K., Essen, L.-O., van der Horst, G. T. J., Batschauer, A., & Ahmad, M. (2011) · Annual Review of Plant Biology · doi:10.1146/annurev-arplant-042110-103759 · Cited by 845 · see citing works
Melanopsin is required for non-image-forming photic responses in blind mice
Panda, S., Provencio, I., Tu, D. C., Pires, S. S., Rollag, M. D., Castrucci, A. M., Pletcher, M. T., Sato, T. K., Wiltshire, T., Andahazy, M., et al. (2003) · Science · doi:10.1126/science.1086179 · Cited by 711 · see citing works
Vitaterna, M. H., Selby, C. P., Todo, T., Niwa, H., Thompson, C., Fruechte, E. M., Hitomi, K., Thresher, R. J., Ishikawa, T., Miyazaki, J., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.21.12114 · Cited by 690 · see citing works
Cryptochrome mediates light-dependent magnetosensitivity in Drosophila
Gegear, R. J., Casselman, A., Waddell, S., & Reppert, S. M. (2008) · Nature · doi:10.1038/nature07183 · Cited by 421 · see citing works
Lin (2005) · Genome biology · doi:10.1186/gb-2005-6-5-220 · Cited by 351 · see citing works
Field, M. D., Maywood, E. S., O'Brien, J. A., Weaver, D. R., Reppert, S. M., & Hastings, M. H. (2000) · Neuron · doi:10.1016/s0896-6273(00)80906-x · Cited by 343 · see citing works
Circadian rhythms, time-restricted feeding, and healthy aging
Manoogian, E. N. C., & Panda, S. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2016.12.006 · Cited by 330 · see citing works
Rubin, E. B., Shemesh, Y., Cohen, M., Elgavish, S., Robertson, H. M., & Bloch, G. (2006) · Genome Research · doi:10.1101/gr.5094806 · Cited by 257 · see citing works
Cryptochromes—a potential magnetoreceptor: what do we know and what do we want to know?
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Cryptochrome Mediates Light-Dependent Magnetosensitivity of Drosophila's Circadian Clock
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A <i>PERIOD3</i> variant causes a circadian phenotype and is associated with a seasonal mood trait
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The Coevolution of Blue-Light Photoreception and Circadian Rhythms
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Self-citationAn Overview of Monthly Rhythms and Clocks
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Fukushiro, M., Takeuchi, T., Takeuchi, Y., Hur, S.-P., Sugama, N., Takemura, A., Kubo, Y., Okano, K., & Okano, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028643 · Cited by 47 · see citing works
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Palm, D., Uzoni, A., Simon, F., Fischer, M., Coogan, A., Tucha, O., Thome, J., & Faltraco, F. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.007 · Cited by 20 · see citing works
- Authors
- Emery, P., So, W. V., Kaneko, M., Hall, J. C., & Rosbash, M.
- Affiliations
- Brandeis University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Rosbash, Michael
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 1998-11
- Volume
- 95
- Issue
- 5
- Pages
- 669-679
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2136757266
- Cited by
- 912
- References
- 85
- Citations by year
- 2026: 23 · 2025: 37 · 2024: 28 · 2023: 39 · 2022: 32 · 2021: 36 · 2020: 33 · 2019: 49 · 2018: 50 · 2017: 35 · 2016: 26 · 2015: 22 · 2014: 39 · 2013: 28 · 2012: 18
- FWCI
- 15.36
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurobiology and Insect Physiology Research
- Keywords
- cryptochrome, crying, Drosophila, circadian rhythm, light entrainment, photoreceptors, clock genes, period, TIMELESS, clocks, cycles, transcriptional regulation
- MeSH terms
- Animals, Circadian Rhythm, Drosophila, Eye Proteins, Female, Flavoproteins, Light, Male, Molecular Sequence Data, Nuclear Proteins, Transcription, Genetic, Trans-Activators, Photoreceptor Cells, Invertebrate, Insect Proteins, Drosophila Proteins, Animals, Genetically Modified, Receptors, G-Protein-Coupled, Basic Helix-Loop-Helix Proteins, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins
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