The DOI matches its Crossref record.
Silk Properties Determined by Gland-Specific Expression of a Spider Fibroin Gene Family
Abstract
Spiders produce a variety of silks that range from Lycra-like elastic fibers to Kevlar-like superfibers. A gene family from the spider Araneus diadematus was found to encode silk-forming proteins (fibroins) with different proportions of amorphous glycine-rich domains and crystal domains built from poly(alanine) and poly(glycine-alanine) repeat motifs. Spiders produce silks of different composition by gland-specific expression of this gene family, which allows for a range of mechanical properties according to the crystal-forming potential of the constituent fibroins. These principles of fiber property control may be important in the development of genetically engineered structural proteins.
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Citations
Cited by
Altman, G. H., Diaz, F., Jakuba, C., Calabro, T., Horan, R. L., Chen, J., Lu, H., Richmond, J., & Kaplan, D. L. (2003) · Biomaterials · doi:10.1016/s0142-9612(02)00353-8 · Cited by 3,458
Liquid crystalline spinning of spider silk
Vollrath, F., & Knight, D. P. (2001) · Nature · doi:10.1038/35069000 · Cited by 1,610
Biomimetic materials for tissue engineering
Ma, P. X. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.041 · Cited by 1,310
Scaffolds for tissue fabrication
Ma, P. X. (2004) · Materials Today · doi:10.1016/s1369-7021(04)00233-0 · Cited by 1,077
Elastomeric biomaterials for tissue engineering
Chen, Q., Liang, S., & Thouas, G. A. (2013) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2012.05.003 · Cited by 564
Metadata
- Authors
- Guerette, P. A., Ginzinger, D. G., Weber, B. H. F., & Gosline, J. M.
- Venue
- Science
- Published
- 1996-04-05
- Volume
- 272
- Issue
- 5258
- Pages
- 112-115
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992516996
- Cited by
- 407
- References
- 0
- FWCI
- 9.44
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Silk Properties Determined by Gland-Specific Expression of a Spider Fibroin Gene Family. https://app.cochat.ai/papers/10.1126/science.272.5258.112
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- Guerette, P. A., Ginzinger, D. G., Weber, B. H. F., & Gosline, J. M. (1996). Silk Properties Determined by Gland-Specific Expression of a Spider Fibroin Gene Family. Science. https://doi.org/10.1126/science.272.5258.112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
