The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Two Genetically Separable Steps in the Differentiation of Thymic Epithelium
Abstract
The development of the thymus depends initially on epithelial-mesenchymal and subsequently on reciprocal lympho-stromal interactions. The genetic steps governing development and differentiation of the thymic microenvironment are unknown. With the use of a targeted disruption of the whn gene, which recapitulates the phenotype of the athymic nude mouse, the WHN transcription factor was shown to be the product of the nude locus. Formation of the thymic epithelial primordium before the entry of lymphocyte progenitors did not require the activity of WHN. However, subsequent differentiation of primitive precursor cells into subcapsular, cortical, and medullary epithelial cells of the postnatal thymus did depend on activity of the whn gene. These results define the first genetically separable steps during thymic epithelial differentiation.
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Cites
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Self-citationThe Oncogenic Cysteine-rich LIM domain protein Rbtn2 is essential for erythroid development
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Self-citationPositive Selection of Thymocytes
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Cited by
p63 Is Essential for the Proliferative Potential of Stem Cells in Stratified Epithelia
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DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES
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Transferrin receptor is necessary for development of erythrocytes and the nervous system
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Contributions of Age-Related Thymic Involution to Immunosenescence and Inflammaging
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Changes in primary lymphoid organs with aging
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Metadata
- Authors
- Nehls, M., Kyewski, B., Messerle, M., Waldschütz, R., Schüddekopf, K., Smith, A. J. H., & Boehm, T.
- Venue
- Science
- Published
- 1996-05-10
- Volume
- 272
- Issue
- 5263
- Pages
- 886-889
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1999928832
- Cited by
- 451
- References
- 21
- FWCI
- 6.50
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nehls, M., Kyewski, B., Messerle, M., Waldschütz, R., Schüddekopf, K., Smith, A. J. H., & Boehm, T. (1996). Two Genetically Separable Steps in the Differentiation of Thymic Epithelium. Science. https://doi.org/10.1126/science.272.5263.886
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
