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Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors.
Abstract
Research on the specificities, functions, and maturation of T cells would be greatly aided by a collection of monoclonal antibodies which distinguishes different types of TCR. With this end in mind hamsters were immunized and tested for production of pan-reactive anti-mouse alpha beta TCR antibodies. In this report we describe the properties and uses of a mAb, H57-597, produced from one of these animals. The mAb reacts with surface receptors on all alpha beta TCR-bearing cells and does not react with receptors on gamma delta+ T cells. In an immobilized form, this antibody can directly activate T cells bearing alpha beta TCR. It can be used in immunoprecipitation reactions to precipitate receptor from the appropriate cell types. In combination with anti-CD3, the antibody can be used in cytofluorographic analyses to measure numbers of CD3+, alpha beta+, and CD3+, gamma delta+ cells in the thymus and periphery.
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Cited by
Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
Pircher, H., Bürki, K., Lang, R., Hengartner, H., & Zinkernagel, R. M. (1989) · Nature · doi:10.1038/342559a0 · Cited by 1,019
BAIN, G. (1994) · Cell · doi:10.1016/0092-8674(94)90077-9 · Cited by 635
MHC Class I Deficiency: Susceptibility to Natural Killer (NK) Cells and Impaired NK Activity
Liao, N.-S., Bix, M., Zijlstra, M., Jaenisch, R., & Raulet, D. (1991) · Science · doi:10.1126/science.1853205 · Cited by 490
Two Genetically Separable Steps in the Differentiation of Thymic Epithelium
Nehls, M., Kyewski, B., Messerle, M., Waldschütz, R., Schüddekopf, K., Smith, A. J. H., & Boehm, T. (1996) · Science · doi:10.1126/science.272.5263.886 · Cited by 451
T Cell Receptor-MHC Class I Peptide Interactions: Affinity, Kinetics, and Specificity
Fisher, R. J., & Fivash, M. (1995) · Science · doi:10.1126/science.7701331 · Cited by 296
Metadata
- Authors
- Kubo, R. T., Born, W., Kappler, J. W., Marrack, P., & Pigeon, M.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 1989-04
- Volume
- 142
- Issue
- 8
- Pages
- 2736-2742
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W1621064629
- Cited by
- 747
- References
- 0
- FWCI
- 30.86
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kubo, R. T., Born, W., Kappler, J. W., Marrack, P., & Pigeon, M. (1989). Characterization of a monoclonal antibody which detects all murine alpha beta T cell receptors. The Journal of Immunology. https://doi.org/10.4049/jimmunol.142.8.2736
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