The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1
Abstract
Transcription factors of the NFAT family are thought to play a major role in regulating the expression of cytokine genes and other inducible genes during the immune response. The role of NFAT1 was investigated by targeted disruption of the NFAT1 gene. Unexpectedly, cells from NFAT1 −/− mice showed increased primary responses to Leishmania major and mounted increased secondary responses to ovalbumin in vitro. In an in vivo model of allergic inflammation, the accumulation of eosinophils and levels of serum immunoglobulin E were increased in NFAT1 −/− mice. These results suggest that NFAT1 exerts a negative regulatory influence on the immune response.
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Cites
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Cited by
TRANSCRIPTION FACTORS OF THE NFAT FAMILY:Regulation and Function
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The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells
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“P14+Tcra / mice were further crossed with NFAT1-deficient mice (Xanthoudakis et al., 1996) and with mice deficient in NFAT2 in the T cell lineage, obtained by breeding CD4Cre mice with mice in which exon 3 of the gene encoding NFAT2 was ‘‘floxed’’ (flanked with LoxP sites) (Figure S5A).”
InfluentialSelf-citationTranscriptional Mechanisms Underlying Lymphocyte Tolerance
Macián, F., Garcı́a-Cózar, F., Im, S.-H., Horton, H. F., Byrne, M. C., & Rao, A. (2002) · Cell · doi:10.1016/s0092-8674(02)00767-5 · Cited by 687
Self-citationLineage commitment in the immune system: the T helper lymphocyte grows up
Glimcher, L. H., & Murphy, K. M. (2000) · Genes & Development · doi:10.1101/gad.14.14.1693 · Cited by 623
Metadata
- Authors
- Xanthoudakis, S., Viola, J. P. B., Shaw, K. T. Y., Luo, C., Wallace, J. D., Bozza, P. T., Luk, D. C., Curran, T., & Rao, A.
- Venue
- Science
- Published
- 1996-05-10
- Volume
- 272
- Issue
- 5263
- Pages
- 892-895
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994894837
- Cited by
- 366
- References
- 50
- FWCI
- 9.52
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xanthoudakis, S., Viola, J. P. B., Shaw, K. T. Y., Luo, C., Wallace, J. D., Bozza, P. T., Luk, D. C., Curran, T., & Rao, A. (1996). An Enhanced Immune Response in Mice Lacking the Transcription Factor NFAT1. Science. https://doi.org/10.1126/science.272.5263.892
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