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Specification of Pituitary Cell Lineages by the LIM Homeobox Gene Lhx3
Abstract
During pituitary organogenesis, the progressive differentiation of distinct pituitary-specific cell lineages from a common primordium involves a series of developmental decisions and inductive interactions. Targeted gene disruption in mice showed that Lhx3 , a LIM homeobox gene expressed in the pituitary throughout development, is essential for differentiation and proliferation of pituitary cell lineages. In mice homozygous for the Lhx3 mutation, Rathke's pouch formed but failed to grow and differentiate; such mice lacked both the anterior and intermediate lobes of the pituitary. The determination of all pituitary cell lineages, except the corticotrophs, was affected, suggesting that a distinct, Lhx3 -independent ontogenetic pathway exists for the initial specification of this lineage.
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Citations
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
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Cited by
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Recent advances in central congenital hypothyroidism
Schoenmakers, N., Alatzoglou, K. S., Chatterjee, V. K., & Dattani, M. T. (2015) · Journal of Endocrinology · doi:10.1530/joe-15-0341 · Cited by 125
Pituitary transcription factors in the aetiology of combined pituitary hormone deficiency
Pfäffle, R., & Klammt, J. (2011) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2010.10.014 · Cited by 115
The PTX family of homeodomain transcription factors during pituitary developments
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ERK Signaling in the Pituitary Is Required for Female But Not Male Fertility
Bliss, S. P., Miller, A., Navratil, A. M., Xie, J., McDonough, S. P., Fisher, P. J., Landreth, G. E., & Roberson, M. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0030 · Cited by 91
The origins of the circumventricular organs
Kiecker, C. (2018) · Journal of Anatomy · doi:10.1111/joa.12771 · Cited by 92
Trowe, M.-O., Zhao, L., Weiss, A.-C., Christoffels, V., Epstein, D. J., & Kispert, A. (2013) · Development · doi:10.1242/dev.094524 · Cited by 72
Verdejo-Torres, O., Klein, D. C., Novoa-Aponte, L., Carrazco-Carrillo, J., Bonilla-Pinto, D., Rivera, A., Bakhshian, A., Fitisemanu, F. M., Jiménez-González, M. L., Flinn, L., et al. (2024) · PLOS Genetics · doi:10.1371/journal.pgen.1011495 · Cited by 10
Metadata
- Authors
- Sheng, H. Z., Zhadanov, A. B., Mosinger, B., Fujii, T., Bertuzzi, S., Grinberg, A., Lee, E. J., Huang, S.-P., Mahon, K. A., & Westphal, H.
- Venue
- Science
- Published
- 1996-05-17
- Volume
- 272
- Issue
- 5264
- Pages
- 1004-1007
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2018216158
- Cited by
- 458
- References
- 2
- FWCI
- 11.13
- Type
- journal article
- Language
- en
- Open access
- closed
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