The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling
Abstract
The threshold at which antigen triggers lymphocyte activation is set by the enzymes that regulate tyrosine phosphorylation. Upon T cell activation, the protein tyrosine phosphatase SHP-1 was found to bind to the protein tyrosine kinase ZAP-70. This interaction resulted in an increase in SHP-1 phosphatase activity and a decrease in ZAP-70 kinase activity. Expression of a dominant negative mutant of SHP-1 in T cells increased the sensitivity of the antigen receptor. Thus, SHP-1 functions as a negative regulator of the T cell antigen receptor and in setting the threshold of activation.
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A Role in B Cell Activation for CD22 and the Protein Tyrosine Phosphatase SHP
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Self-citationRecruitment and Activation of PTP1C in Negative Regulation of Antigen Receptor Signaling by FcγRIIB1
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Riley, J. L. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2009.00767.x · Cited by 778
Yasukawa, H., Misawa, H., Sakamoto, H., Masuhara, M., Sasaki, A., Wakioka, T., Ohtsuka, S., Imaizumi, T., Matsuda, T., Ihle, J. N., et al. (1999) · The EMBO Journal · doi:10.1093/emboj/18.5.1309 · Cited by 719
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Metadata
- Authors
- Plas, D. R., Johnson, R., Pingel, J. T., Matthews, R. J., Dalton, M., Roy, G., Chan, A. C., & Thomas, M. L.
- Venue
- Science
- Published
- 1996-05-24
- Volume
- 272
- Issue
- 5265
- Pages
- 1173-1176
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1979769420
- Cited by
- 390
- References
- 20
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling. https://app.cochat.ai/papers/10.1126/science.272.5265.1173
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- Plas, D. R., Johnson, R., Pingel, J. T., Matthews, R. J., Dalton, M., Roy, G., Chan, A. C., & Thomas, M. L. (1996). Direct Regulation of ZAP-70 by SHP-1 in T Cell Antigen Receptor Signaling. Science. https://doi.org/10.1126/science.272.5265.1173
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
