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Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation
Abstract
Tyrosine kinases indirectly raise intracellular calcium concentration ([Ca 2+ ] i ) by activating phospholipases that generate inositol 1,4,5-trisphosphate (IP 3 ). IP 3 activates the IP 3 receptor (IP 3 R), an intracellular calcium release channel on the endoplasmic reticulum. T cell receptor stimulation triggered a physical association between the nonreceptor protein tyrosine kinase Fyn and the IP 3 R, which induced tyrosine phosphorylation of the IP 3 R. Fyn activated an IP 3 -gated calcium channel in vitro, and tyrosine phosphorylation of the IP 3 R during T cell activation was reduced in thymocytes from fyn −/− mice. Thus, activation of the IP 3 R by tyrosine phosphorylation may play a role in regulating [Ca 2+ ] i .
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Citations
Cited by
Inositol Trisphosphate Receptor Ca2+Release Channels
Foskett, J. K., White, C., Cheung, K.-H., & Mak, D.-O. D. (2007) · Physiological Reviews · doi:10.1152/physrev.00035.2006 · Cited by 1,188
Silva, E., Rajapakse, N., & Kortenkamp, A. (2002) · Environmental Science & Technology · doi:10.1021/es0101227 · Cited by 912
Calcium signaling mechanisms in T lymphocytes.
Lewis, R. S. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.497 · Cited by 860
Physiology and Pathophysiology of the Calcium Store in the Endoplasmic Reticulum of Neurons
Verkhratsky, A. (2005) · Physiological Reviews · doi:10.1152/physrev.00004.2004 · Cited by 709
Inositol 1,4,5-Trisphosphate Receptors as Signal Integrators
Patterson, R. L., Boehning, D., & Snyder, S. H. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.161303 · Cited by 441
Metadata
- Authors
- Jayaraman, T., Ondrias, K., Ondria, E., & Marks, A. R.
- Venue
- Science
- Published
- 1996-06-07
- Volume
- 272
- Issue
- 5267
- Pages
- 1492-1494
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2035920388
- Cited by
- 209
- References
- 0
- FWCI
- 13.45
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation. https://app.cochat.ai/papers/10.1126/science.272.5267.1492
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- Jayaraman, T., Ondrias, K., Ondria, E., & Marks, A. R. (1996). Regulation of the Inositol 1,4,5-Trisphosphate Receptor by Tyrosine Phosphorylation. Science. https://doi.org/10.1126/science.272.5267.1492
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
