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Cited by 1,911Stroke Rehabilitation and RecoveryMotor Control and AdaptationTranscranial Magnetic Stimulation Studies

The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.

Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct

Nudo, Randolph J., Wise, Birute M., SiFuentes, Frank, Milliken, Garrett W.·1996·Science
DOI 10.1126/science.272.5269.1791
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Abstract

Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.

Overview

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Registry

Crossref · 10.1126/science.272.5269.1791

Cites

33 of 33 references verified0 citation errors · 0 not checkable

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Citations

Cites

Research works printed but not linked: 7

  1. BACHYRITA P, RECOVERY FUNCTION TH: 225 (1980).
  2. BLACK P, OUTCOME SEVERE DAMAG: 65 (1975).
  3. BLACK P, T AM NEUROL ASSOC 95, 207 (1970).
  4. BUCY P.C., PRECENTRAL MOTOR COR: 353 (1944).
  5. GOWLAND C, STROKE REHABILITATIO: 217 (1987).
  6. NUDO R.J., SOC NEUR ABSTR 21, 517 (1995).
  7. TRAVIS A.M., AM J PHYS MED 35, 273 (1956).

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Metadata

Authors
Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W.
Affiliations
The University of Texas Health Science Center at Houston (US)
Corresponding author
  • Nudo, Randolph J.
  • Milliken, Garrett W.
ORCID
Nudo, Randolph J.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-06-21
Volume
272
Issue
5269
Pages
1791-1794
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.272.5269.1791
OpenAlex
W2038514344
Cited by
1,911
References
33
Citations by year
2026: 34 · 2025: 38 · 2024: 35 · 2023: 51 · 2022: 61 · 2021: 56 · 2020: 34 · 2019: 59 · 2018: 46 · 2017: 71 · 2016: 71 · 2015: 77 · 2014: 82 · 2013: 79 · 2012: 77
FWCI
52.86
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29ns027974-05)
  • National Institute of Neurological Disorders and Stroke (NS27974, NS30853)
Topics
  • Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
  • Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
Keywords
motor cortex, functional reorganization, ischemic infarct, stroke, motor recovery, rehabilitative training, hand representation, squirrel monkey, cortical plasticity
MeSH terms
Animals, Brain Mapping, Cerebral Infarction, Brain Ischemia, Electric Stimulation, Hand, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Random Allocation, Saimiri

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