The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Neural Substrates for the Effects of Rehabilitative Training on Motor Recovery After Ischemic Infarct
Abstract
Substantial functional reorganization takes place in the motor cortex of adult primates after a focal ischemic infarct, as might occur in stroke. A subtotal lesion confined to a small portion of the representation of one hand was previously shown to result in a further loss of hand territory in the adjacent, undamaged cortex of adult squirrel monkeys. In the present study, retraining of skilled hand use after similar infarcts resulted in prevention of the loss of hand territory adjacent to the infarct. In some instances, the hand representations expanded into regions formerly occupied by representations of the elbow and shoulder. Functional reorganization in the undamaged motor cortex was accompanied by behavioral recovery of skilled hand function. These results suggest that, after local damage to the motor cortex, rehabilitative training can shape subsequent reorganization in the adjacent intact cortex, and that the undamaged motor cortex may play an important role in motor recovery.
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“From the motor learning perspectives, when children with CP learn a motor skill, it required hundreds of repetitions per day of a challenging functional task to lead to structural neurological change.62,63”
From Effectiveness of Virtual Reality in Children With Cerebral Palsy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (2018) · cites this paper as [63]
Citations
Cites
Functional MRI evidence for adult motor cortex plasticity during motor skill learning
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Massive Cortical Reorganization After Sensory Deafferentation in Adult Macaques
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Cited by
Sorted by citations
Plasticity during stroke recovery: from synapse to behaviour
Murphy, T. H., & Corbett, D. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2735 · Cited by 1,938
Robot-aided neurorehabilitation
Krebs, H. I., Hogan, N., Aisen, M. L., & Volpe, B. T. (1998) · IEEE Transactions on Rehabilitation Engineering · doi:10.1109/86.662623 · Cited by 1,432
Treatment-Induced Cortical Reorganization After Stroke in Humans
Liepert, J., Bauder, H., Miltner, W. H. R., Taub, E., & Weiller, C. (2000) · Stroke · doi:10.1161/01.str.31.6.1210 · Cited by 1,406
Motor learning: its relevance to stroke recovery and neurorehabilitation
Krakauer, J. W. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000200544.29915.cc · Cited by 1,282
Harnessing neuroplasticity for clinical applications
Cramer, S. C., Sur, M., Dobkin, B. H., O'Brien, C., Sanger, T. D., Trojanowski, J. Q., Rumsey, J. M., Hicks, R., Cameron, J., Chen, D., et al. (2011) · Brain · doi:10.1093/brain/awr039 · Cited by 1,259
Metadata
- Authors
- Nudo, R. J., Wise, B. M., SiFuentes, F., & Milliken, G. W.
- Affiliations
- The University of Texas Health Science Center at Houston (US)
- Corresponding author
- Nudo, Randolph J.
- Milliken, Garrett W.
- ORCID
- Nudo, Randolph J.
- Venue
- Science
- Published
- 1996-06-21
- Volume
- 272
- Issue
- 5269
- Pages
- 1791-1794
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038514344
- Cited by
- 1,911
- References
- 33
- Citations by year
- 2026: 34 · 2025: 38 · 2024: 35 · 2023: 51 · 2022: 61 · 2021: 56 · 2020: 34 · 2019: 59 · 2018: 46 · 2017: 71 · 2016: 71 · 2015: 77 · 2014: 82 · 2013: 79 · 2012: 77
- FWCI
- 52.86
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29ns027974-05)
- National Institute of Neurological Disorders and Stroke (NS27974, NS30853)
- Topics
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- motor cortex, functional reorganization, ischemic infarct, stroke, motor recovery, rehabilitative training, hand representation, squirrel monkey, cortical plasticity
- MeSH terms
- Animals, Brain Mapping, Cerebral Infarction, Brain Ischemia, Electric Stimulation, Hand, Male, Motor Cortex, Motor Skills, Neuronal Plasticity, Random Allocation, Saimiri
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