CoChat
Sign Up
Cited by 207

The DOI matches its Crossref record.

Aberrant B Cell Development and Immune Response in Mice with a Compromised BCR Complex

Torres, Raul M., Flaswinkel, Heinrich, Reth, Michael, Rajewsky, Klaus·1996·Science
DOI 10.1126/science.272.5269.1804
Open this paper in CoChat — free account

Abstract

The immunoglobulin α (Ig-α)-Ig-β heterodimer is the signaling component of the antigen receptor complex on B cells (BCR) and B cell progenitors (pre-BCR). A mouse mutant that lacks most of the Ig-α cytoplasmic tail exhibits only a small impairment in early B cell development but a severe block in the generation of the peripheral B cell pool, revealing a checkpoint in B cell maturation that ensures the expression of a functional BCR on mature B cells. B cells that do develop demonstrate a differential dependence on Ig-α signaling in antibody responses such that a signaling-competent Ig-α appears to be critical for the response to T-independent, but not T-dependent, antigens.

Overview

Integrity signals

Registry

Crossref · 10.1126/science.272.5269.1804

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

No references could be resolved yet.

Research works printed but not linked: 59

  1. ALLMAN D.M., PERIPHERAL B-CELL MATURATION .2. HEAT-STABLE ANTIGEN(HI) SPLENIC B-CELLS ARE AN IMMATURE DEVELOPMENTAL INTERMEDIATE IN THE PRODUCTION OF LONG-LIVED MARROW-DERIVED B-CELLS, JOURNAL OF IMMUNOLOGY 151, 4431 (1993). · DOI
  2. AOKI Y, BRUTON TYROSINE KINASE IS TYROSINE-PHOSPHORYLATED AND ACTIVATED IN PRE-B LYMPHOCYTES AND RECEPTOR-LIGATED B-CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 10606 (1994). · DOI
  3. ASSENMACHER M, FLOW CYTOMETRIC DETERMINATION OF CYTOKINES IN ACTIVATED MURINE T-HELPER LYMPHOCYTES - EXPRESSION OF INTERLEUKIN-10 IN INTERFERON-GAMMA AND IN INTERLEUKIN-4-EXPRESSING CELLS, EUROPEAN JOURNAL OF IMMUNOLOGY 24, 1097 (1994). · DOI
  4. BLUM J.H., ROLE OF THE MU IMMUNOGLOBULIN HEAVY-CHAIN TRANSMEMBRANE AND CYTOPLASMIC DOMAINS IN B-CELL ANTIGEN RECEPTOR EXPRESSION AND SIGNAL-TRANSDUCTION, JOURNAL OF BIOLOGICAL CHEMISTRY 268, 27236 (1993). · DOI
  5. BONNEROT C, ROLE OF B-CELL RECEPTOR IG-ALPHA AND IG-BETA SUBUNITS IN MHC CLASS II-RESTRICTED ANTIGEN PRESENTATION, IMMUNITY 3, 335 (1995). · DOI
  6. BROUNS G.S., THE STRUCTURE OF THE MU PSEUDO LIGHT-CHAIN COMPLEX ON HUMAN PRE-B CELLS IS CONSISTENT WITH A FUNCTION IN SIGNAL-TRANSDUCTION, EUROPEAN JOURNAL OF IMMUNOLOGY 23, 1088 (1993). · DOI
  7. BROWN V.K., MULTIPLE COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX ASSOCIATE WITH THE PROTEIN-TYROSINE-PHOSPHATASE, CD45, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 17238 (1994). · DOI
  8. CAMBIER J.C., ANTIGEN AND FC RECEPTOR SIGNALING - THE AWESOME POWER OF THE IMMUNORECEPTOR TYROSINE-BASED ACTIVATION MOTIF (ITAM), JOURNAL OF IMMUNOLOGY 155, 3281 (1995). · DOI
  9. 10.1126/science.1439759 · DOI
  10. CONLEY M.E., X-LINKED AGAMMAGLOBULINEMIA - NEW APPROACHES TO OLD QUESTIONS BASED ON THE IDENTIFICATION OF THE DEFECTIVE GENE, IMMUNOLOGICAL REVIEWS 138, 5 (1994). · DOI
  11. CONLEY M.E., FEMALES WITH A DISORDER PHENOTYPICALLY IDENTICAL TO X-LINKED AGAMMAGLOBULINEMIA, JOURNAL OF CLINICAL IMMUNOLOGY 12, 139 (1992). · DOI
  12. DEWEERS M, B-CELL ANTIGEN RECEPTOR STIMULATION ACTIVATES THE HUMAN BRUTONS TYROSINE KINASE, WHICH IS DEFICIENT IN X-LINKED AGAMMAGLOBULINEMIA, JOURNAL OF BIOLOGICAL CHEMISTRY 269, 23857 (1994). · DOI
  13. EHLICH A, IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN GENES REARRANGE INDEPENDENTLY AT EARLY STAGES OF B-CELL DEVELOPMENT, CELL 72, 695 (1993). · DOI
  14. FLASWINKEL H, DUAL ROLE OF THE TYROSINE ACTIVATION MOTIF OF THE IG-ALPHA PROTEIN DURING SIGNAL-TRANSDUCTION VIA THE B-CELL ANTIGEN RECEPTOR, EMBO JOURNAL 13, 83 (1994). · DOI
  15. FORSTER I, EXPANSION AND FUNCTIONAL-ACTIVITY OF LY-1+ B-CELLS UPON TRANSFER OF PERITONEAL-CELLS INTO ALLOTYPE-CONGENIC, NEWBORN MICE, EUROPEAN JOURNAL OF IMMUNOLOGY 17, 521 (1987). · DOI
  16. GILFILLAN S, MORE EFFICIENT POSITIVE SELECTION OF THYMOCYTES IN MICE LACKING TERMINAL DEOXYNUCLEOTIDYL TRANSFERASE, INTERNATIONAL IMMUNOLOGY 6, 1681 (1994). · DOI
  17. GRUPP S.A., SIGNALING-DEFECTIVE MUTANTS OF THE B-LYMPHOCYTE ANTIGEN RECEPTOR FAIL TO ASSOCIATE WITH IG-ALPHA AND IG-BETA/GAMMA, JOURNAL OF BIOLOGICAL CHEMISTRY 268, 25776 (1993). · DOI
  18. HARDY R.R., CD5 B-CELLS, A FETAL B-CELL LINEAGE, ADVANCES IN IMMUNOLOGY, VOL 55 55, 297 (1994). · DOI
  19. HARDY R.R., RESOLUTION AND CHARACTERIZATION OF PRO-B AND PRE-PRO-B CELL STAGES IN NORMAL MOUSE BONE-MARROW, JOURNAL OF EXPERIMENTAL MEDICINE 173, 1213 (1991). · DOI
  20. HINSHELWOOD S, THE PROTEIN DEFECTIVE IN X-LINKED AGAMMAGLOBULINEMIA, BRUTONS TYROSINE KINASE, SHOWS INCREASED AUTOPHOSPHORYLATION ACTIVITY IN-VITRO WHEN ISOLATED FROM CELLS IN WHICH THE B-CELL RECEPTOR HAS BEEN CROSS-LINKED, EUROPEAN JOURNAL OF IMMUNOLOGY 25, 1113 (1995). · DOI
  21. HOMBACH J, IDENTIFICATION OF THE GENES ENCODING THE IGM-ALPHA AND IG-BETA COMPONENTS OF THE IGM ANTIGEN RECEPTOR COMPLEX BY AMINO-TERMINAL SEQUENCING, EUROPEAN JOURNAL OF IMMUNOLOGY 20, 2795 (1990). · DOI
  22. HOMBACH J, MOLECULAR-COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX OF THE IGM CLASS, NATURE 343, 760 (1990). · DOI
  23. JACK R.S., IDIOTYPIC ANALYSIS OF RESPONSE OF C57BL-6 MICE TO (4-HYDROXY-3-NITROPHENYL)ACETYL GROUP, EUROPEAN JOURNAL OF IMMUNOLOGY 7, 559 (1977). · DOI
  24. KAHN W.N., IMMUNITY 3, 283 (1995). · DOI
  25. KASHIWAMURA S.I., STRUCTURE OF THE MURINE MB-1 GENE ENCODING A PUTATIVE SIGM-ASSOCIATED MOLECULE, JOURNAL OF IMMUNOLOGY 145, 337 (1990). · DOI
  26. KERNER J.D., IMPAIRED EXPANSION OF MOUSE B-CELL PROGENITORS LACKING BTK, IMMUNITY 3, 301 (1995). · DOI
  27. KIM K.M., DIFFERENTIAL SIGNALING THROUGH THE IG-ALPHA AND IG-BETA COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR, EUROPEAN JOURNAL OF IMMUNOLOGY 23, 911 (1993). · DOI
  28. KITAMURA D, A CRITICAL ROLE OF LAMBDA-5 PROTEIN IN B-CELL DEVELOPMENT, CELL 69, 823 (1992). · DOI · Paper page
  29. KITAMURA D, TARGETED DISRUPTION OF MU-CHAIN MEMBRANE EXON CAUSES LOSS OF HEAVY-CHAIN ALLELIC EXCLUSION, NATURE 356, 154 (1992). · DOI · Paper page
  30. LAW D.A., B-CELL ANTIGEN RECEPTOR MOTIFS HAVE REDUNDANT SIGNALING CAPABILITIES AND BIND THE TYROSINE KINASES PTK72, LYN AND FYN, CURRENT BIOLOGY 3, 645 (1993). · DOI
  31. LEDERMANN B, ESTABLISHMENT OF A GERM-LINE COMPETENT C57BL/6 EMBRYONIC STEM-CELL LINE, EXPERIMENTAL CELL RESEARCH 197, 254 (1991). · DOI
  32. LIN J.J., THE MB-1/B29 HETERODIMER COUPLES THE B-CELL ANTIGEN RECEPTOR TO MULTIPLE SRC FAMILY PROTEIN TYROSINE KINASES, JOURNAL OF IMMUNOLOGY 149, 1548 (1992). · DOI
  33. LOFFERT D, Surrogate light chain expression is required to establish immunoglobulin heavy chain allelic exclusion during early B cell development, IMMUNITY 4, 133 (1996). · DOI
  34. LOFFERT D, EARLY B-CELL DEVELOPMENT IN THE MOUSE - INSIGHTS FROM MUTATIONS INTRODUCED BY GENE TARGETING, IMMUNOLOGICAL REVIEWS 137, 135 (1994). · DOI
  35. MATSUO T, CROSS-LINKING OF B-CELL RECEPTOR-RELATED MB-1 MOLECULE INDUCES PROTEIN TYROSINE PHOSPHORYLATION IN EARLY B-LINEAGE CELLS, JOURNAL OF IMMUNOLOGY 150, 3766 (1993). · DOI
  36. MATSUUCHI L, THE MEMBRANE IGM-ASSOCIATED PROTEINS MB-1 AND IG-BETA ARE SUFFICIENT TO PROMOTE SURFACE EXPRESSION OF A PARTIALLY FUNCTIONAL B-CELL ANTIGEN RECEPTOR IN A NONLYMPHOID CELL-LINE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89, 3404 (1992). · DOI
  37. MOND J.J., T-CELL-INDEPENDENT ANTIGENS TYPE-2, ANNUAL REVIEW OF IMMUNOLOGY 13, 655 (1995). · DOI
  38. OPSTELTEN D, PRE-B-CELLS IN MOUSE BONE-MARROW - IMMUNOFLUORESCENCE STATHMOKINETIC STUDIES OF THE PROLIFERATION OF CYTOPLASMIC MU-CHAIN-BEARING CELLS IN NORMAL MICE, JOURNAL OF IMMUNOLOGY 131, 2635 (1983). · DOI
  39. 10.1126/science.7716544 · DOI
  40. PATEL K.J., ANTIGEN PRESENTATION BY THE B-CELL ANTIGEN RECEPTOR IS DRIVEN BY THE ALPHA-BETA SHEATH AND OCCURS INDEPENDENTLY OF ITS CYTOPLASMIC TYROSINES, CELL 74, 939 (1993). · DOI
  41. RAJEWSKY K, EARLY AND LATE B-CELL DEVELOPMENT IN THE MOUSE, CURRENT OPINION IN IMMUNOLOGY 4, 171 (1992). · DOI
  42. RAJEWSKY K, SPECIFICITY AND HETEROGENEITY OF HELPER T-CELLS IN RESPONSE TO SERUM ALBUMINS IN MICE, EUROPEAN JOURNAL OF IMMUNOLOGY 4, 111 (1974). · DOI
  43. 10.1126/science.8332901 · DOI
  44. 10.1038/338383b0 · DOI
  45. RICKERT R.C., IMPAIRMENT OF T-CELL-DEPENDENT B-CELL RESPONSES AND B-1 CELL-DEVELOPMENT IN CD19-DEFICIENT MICE, NATURE 376, 352 (1995). · DOI
  46. ROES J, IMMUNOGLOBULIN-D (IGD)-DEFICIENT MICE REVEAL AN AUXILIARY RECEPTOR FUNCTION FOR IGD IN ANTIGEN-MEDIATED RECRUITMENT OF B-CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 177, 45 (1993). · DOI
  47. ROLINK A, IL-2 RECEPTOR-ALPHA CHAIN (CD25,TAC) EXPRESSION DEFINES A CRUCIAL STAGE IN PRE-B-CELL DEVELOPMENT, INTERNATIONAL IMMUNOLOGY 6, 1257 (1994). · DOI
  48. ROWLEY R.B., SYK PROTEIN-TYROSINE KINASE IS REGULATED BY TYROSINE-PHOSPHORYLATED IG-ALPHA IG-BETA IMMUNORECEPTOR TYROSINE ACTIVATION MOTIF BINDING AND AUTOPHOSPHORYLATION, JOURNAL OF BIOLOGICAL CHEMISTRY 270, 11590 (1995). · DOI
  49. SANCHEZ M, SIGNAL-TRANSDUCTION BY IMMUNOGLOBULIN IS MEDIATED THROUGH IG-ALPHA AND IG-BETA, JOURNAL OF EXPERIMENTAL MEDICINE 178, 1049 (1993). · DOI
  50. SAOUAF S.J., TEMPORAL DIFFERENCES IN THE ACTIVATION OF 3 CLASSES OF NONTRANSMEMBRANE PROTEIN-TYROSINE KINASES FOLLOWING B-CELL ANTIGEN RECEPTOR SURFACE ENGAGEMENT, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 91, 9524 (1994). · DOI
  51. SPANOPOULOU E, FUNCTIONAL IMMUNOGLOBULIN TRANSGENES GUIDE ORDERED B-CELL DIFFERENTIATION IN RAG-1-DEFICIENT MICE, GENES & DEVELOPMENT 8, 1030 (1994). · DOI
  52. 10.1126/science.8332900 · DOI
  53. TORRES R.M., IN PRESS LAB PROTOCO (1996).
  54. TSUKADA S, DEFICIENT EXPRESSION OF A B-CELL CYTOPLASMIC TYROSINE KINASE IN HUMAN X-LINKED AGAMMAGLOBULINEMIA, CELL 72, 279 (1993). · DOI
  55. VENKITARAMAN A.R., THE B-CELL ANTIGEN RECEPTOR OF THE 5 IMMUNOGLOBULIN CLASSES, NATURE 352, 777 (1991). · DOI
  56. VETRIE D, THE GENE INVOLVED IN X-LINKED AGAMMAGLOBULINEMIA IS A MEMBER OF THE SRC FAMILY OF PROTEIN-TYROSINE KINASES, NATURE 361, 226 (1993). · DOI
  57. WICKER L.S., X-LINKED IMMUNE-DEFICIENCY (XID) OF CBA/N MICE, CURRENT TOPICS IN MICROBIOLOGY AND IMMUNOLOGY 124, 87 (1986).
  58. WIENANDS J, THESIS U FREIBURG GE (1990).
  59. YOUNG F, INFLUENCE OF IMMUNOGLOBULIN HEAVY-CHAIN AND LIGHT-CHAIN EXPRESSION ON B-CELL DIFFERENTIATION, GENES & DEVELOPMENT 8, 1043 (1994). · DOI

Cited by

Sorted by citations

Metadata

Authors
Torres, R. M., Flaswinkel, H., Reth, M., & Rajewsky, K.
Affiliations
  • R. M. Torres and K. Rajewsky, Institute for Genetics, University of Cologne, Weyertal 121, D-50931 Cologne, Germany.
  • H. Flaswinkel and M. Reth, Max Planck Institute for Immunobiology, 79108 Freiburg, Germany.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-06-21
Volume
272
Issue
5269
Pages
1804-1808
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.272.5269.1804
Cited by
207
References
0
Language
en

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review