The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin
Abstract
Random phage display peptide libraries and affinity selective methods were used to isolate small peptides that bind to and activate the receptor for the cytokine erythropoietin (EPO). In a panel of in vitro biological assays, the peptides act as full agonists and they can also stimulate erythropoiesis in mice. These agonists are represented by a 14- amino acid disulfide-bonded, cyclic peptide with the minimum consensus sequence YXCXXGPXTWXCXP, where X represents positions allowing occupation by several amino acids. The amino acid sequences of these peptides are not found in the primary sequence of EPO. The signaling pathways activated by these peptides appear to be identical to those induced by the natural ligand. This discovery may form the basis for the design of small molecule mimetics of EPO.
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Damen, J., Liu, L., Cutler, R., & Krystal, G. (1993) · Blood · doi:10.1182/blood.v82.8.2296.2296 · Cited by 193
Cited by
Hunter, T. (2000) · Cell · doi:10.1016/s0092-8674(00)81688-8 · Cited by 2,586
Small-molecule inhibitors of protein–protein interactions: progressing towards the dream
Arkin, M. R., & Wells, J. A. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1343 · Cited by 1,705
Designing a polyvalent inhibitor of anthrax toxin
Mourez, M., Kane, R. S., Mogridge, J., Metallo, S., Deschatelets, P., Sellman, B. R., Whitesides, G. M., & Collier, R. J. (2001) · Nature Biotechnology · doi:10.1038/nbt1001-958 · Cited by 272
Bunn, H. F. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a011619 · Cited by 234
The pleiotropic effects of erythropoietin in infection and inflammation
Nairz, M., Sonnweber, T., Schroll, A., Theurl, I., & Weiss, G. (2012) · Microbes and Infection · doi:10.1016/j.micinf.2011.10.005 · Cited by 161
Metadata
- Authors
- Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., & Dower, W. J.
- Venue
- Science
- Published
- 1996-07-26
- Volume
- 273
- Issue
- 5274
- Pages
- 458-463
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1987888718
- Cited by
- 672
- References
- 1
- FWCI
- 33.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wrighton, N. C., Farrell, F. X., Chang, R., Kashyap, A. K., Barbone, F. P., Mulcahy, L. S., Johnson, D. L., Barrett, R. W., Jolliffe, L. K., & Dower, W. J. (1996). Small Peptides as Potent Mimetics of the Protein Hormone Erythropoietin. Science. https://doi.org/10.1126/science.273.5274.458
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
