The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Demethylation-Induced Developmental Pleiotropy in Arabidopsis
Abstract
The function of DNA methylation in higher plants was investigated by expression of a complementary DNA encoding a cytosine methyltransferase (MET1) from Arabidopsis thaliana as an antisense RNA in transgenic plants. This expression resulted in a 34 to 71 percent reduction in total genomic cytosine methylation. Loss of methylation was observed in both repetitive DNA and single-copy gene sequences. Developmental effects included altered heterochrony, changes in meristem identity and organ number, and female sterility. Cytosine demethylation prolonged both vegetative and reproductive phases of development. These findings implicate DNA methylation in establishing or maintaining epigenetic developmental states in the meristem.
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Citations
Cites
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
Li, E., Bestor, T. H., & Jaenisch, R. (1992) · Cell · doi:10.1016/0092-8674(92)90611-f · Cited by 3,984
Cited by
Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation
Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., & Jacobsen, S. E. (2001) · Science · doi:10.1126/science.1059745 · Cited by 938
Regulation and function of DNA methylation in plants and animals
He, X.-J., Chen, T., & Zhu, J.-K. (2011) · Cell Research · doi:10.1038/cr.2011.23 · Cited by 555
DNA Methylation and Epigenetic Inheritance in Plants and Filamentous Fungi
Martienssen, R. A., & Colot, V. (2001) · Science · doi:10.1126/science.293.5532.1070 · Cited by 517
DNA METHYLATION AND EPIGENETICS
Bender, J. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141641 · Cited by 371
Genetic Fidelity of Organized Meristem-Derived Micropropagated Plants: A Critical Reappraisal
Rani, V., & Raina, S. N. (2000) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/s11627-000-0059-6 · Cited by 325
Metadata
- Authors
- Ronemus, M. J., Galbiati, M., Ticknor, C., Chen, J., & Dellaporta, S. L.
- Venue
- Science
- Published
- 1996-08-02
- Volume
- 273
- Issue
- 5275
- Pages
- 654-657
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2046584121
- Cited by
- 446
- References
- 1
- FWCI
- 7.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ronemus, M. J., Galbiati, M., Ticknor, C., Chen, J., & Dellaporta, S. L. (1996). Demethylation-Induced Developmental Pleiotropy in Arabidopsis. Science. https://doi.org/10.1126/science.273.5275.654
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
