The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation
Abstract
Epigenetic silenced alleles of the Arabidopsis SUPERMAN locus (the clark kent alleles) are associated with dense hypermethylation at noncanonical cytosines (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors of a hypermethylated clark kent mutant identified nine loss-of-function alleles of CHROMOMETHYLASE3 ( CMT3 ), a novel cytosine methyltransferase homolog. These cmt3 mutants display a wild-type morphology but exhibit decreased CpXpG methylation of the SUP gene and of other sequences throughout the genome. They also show reactivated expression of endogenous retrotransposon sequences. These results show that a non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.
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Cites
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Cited by
Jenuwein, T., & Allis, C. D. (2001) · Science · doi:10.1126/science.1063127 · Cited by 9,756
OsSPL14 promotes panicle branching and higher grain productivity in rice
Miura, K., Ikeda, M., Matsubara, A., Song, X.-J., Ito, M., Asano, K., Matsuoka, M., Kitano, H., & Ashikari, M. (2010) · Nature Genetics · doi:10.1038/ng.592 · Cited by 1,104
DNA methylation pathways and their crosstalk with histone methylation
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Self-citationARGONAUTE4 Control of Locus-Specific siRNA Accumulation and DNA and Histone Methylation
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Self-citationComprehensive Analysis of Silencing Mutants Reveals Complex Regulation of the Arabidopsis Methylome
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Metadata
- Authors
- Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., & Jacobsen, S. E.
- Venue
- Science
- Published
- 2001-06-15
- Volume
- 292
- Issue
- 5524
- Pages
- 2077-2080
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1977171359
- Cited by
- 938
- References
- 18
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., & Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation. Science. https://doi.org/10.1126/science.1059745
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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