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Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c
Abstract
α 2 -Adrenergic receptors (α 2 ARs) are essential components of the neural circuitry regulating cardiovascular function. The role of specific α 2 AR subtypes (α 2a , α 2b , and α 2c ) was characterized with hemodynamic measurements obtained from strains of genetically engineered mice deficient in either α 2b or α 2c receptors. Stimulation of α 2b receptors in vascular smooth muscle produced hypertension and counteracted the clinically beneficial hypotensive effect of stimulating α 2a receptors in the central nervous system. There were no hemodynamic effects produced by disruption of the α 2c subtype. These results provide evidence for the clinical efficacy of more subtype-selective α 2 AR drugs.
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Cited by
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Lynch, G. S., & Ryall, J. G. (2008) · Physiological Reviews · doi:10.1152/physrev.00028.2007 · Cited by 410
Mutant G-protein-coupled receptors as a cause of human diseases
Schöneberg, T., Schulz, A., Biebermann, H., Hermsdorf, T., Römpler, H., & Sangkuhl, K. (2004) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.08.008 · Cited by 337
Pharmacology and physiology of human adrenergic receptor polymorphisms
Small, K. M., McGraw, D. W., & Liggett, S. B. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135823 · Cited by 323
Gene targeting — homing in on α2-adrenoceptor-subtype function
MacDonald, E., Kobilka, B. K., & Scheinin, M. (1997) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01063-8 · Cited by 310
Self-citationG-Protein–Coupled Receptors in Heart Disease
Wang, J., Gareri, C., & Rockman, H. A. (2018) · Circulation Research · doi:10.1161/circresaha.118.311403 · Cited by 303
Metadata
- Authors
- Link, R. E., Desai, K., Hein, L., Stevens, M. E., Chruscinski, A., Bernstein, D., Barsh, G. S., & Kobilka, B. K.
- Venue
- Science
- Published
- 1996-08-09
- Volume
- 273
- Issue
- 5276
- Pages
- 803-805
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2084235775
- Cited by
- 467
- References
- 0
- FWCI
- 8.41
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c. https://app.cochat.ai/papers/10.1126/science.273.5276.803
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- Link, R. E., Desai, K., Hein, L., Stevens, M. E., Chruscinski, A., Bernstein, D., Barsh, G. S., & Kobilka, B. K. (1996). Cardiovascular Regulation in Mice Lacking α 2 -Adrenergic Receptor Subtypes b and c. Science. https://doi.org/10.1126/science.273.5276.803
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
